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Intraperitoneal Steroid Therapy for Recurrent Malignant Ascites in Advanced Cancer Patients: A Case Series.
Clin Case Rep
January 2025
Intraperitoneal administration of depot corticosteroids following an initial paracentesis reduces ascitic fluid formation and extends the interval between subsequent paracentesis sessions. This approach may effectively manage recurrent malignant ascites and enhance patients' quality of life.
View Article and Find Full Text PDFAbscopal Effect in a Patient With Metastatic Melanoma Receiving Hypofractionated Radiation Therapy and Dual Immune Checkpoint Inhibition: A Case Report.
Cureus
November 2024
Radiation Oncology, Fox Chase Cancer Center, Temple University Hospital, Philadelphia, USA.
Concurrent with the increasing utilization of immune checkpoint inhibitors (ICIs) in melanoma, there has been renewed interest in understanding the potential interplay between radiation therapy (RT) and the immune system. One such phenomenon is the abscopal effect, where localized treatments, such as RT, not only shrink the targeted tumor but also induce shrinkage of untreated tumors elsewhere in the body. Here, we report a case of an abscopal effect in a 63-year-old patient with metastatic melanoma who was progressing on first-line dual ICI therapy but experienced a rapid and durable systemic response following the administration of hypofractionated palliative RT to a large primary melanoma skin tumor.
View Article and Find Full Text PDFHIV Disclosure and Low HIV Stigma in a Gay Serodiscordant Couple: An Interpretative Phenomenological Case Study of the Discloser-Confidant Dynamics.
Cureus
November 2024
Department of Radiology, Pain Relief and Palliative Care Unit, Aretaeio Hospital/National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Introduction HIV stigma levels are high in Greece. HIV stigma hinders testing, healthcare access, and treatment adherence, often leading to non-disclosure. The discloser navigates challenges by balancing the confidant's potential reactions, ranging from rejection and discrimination to the benefits of increased intimacy and liking.
View Article and Find Full Text PDFDifficulties and Disparities in Colorectal Cancer End-of-Life Care: A Patient's Story.
Clin Colon Rectal Surg
January 2025
Divisions of Colon and Rectal Surgery and Hospice and Palliative Medicine, Virginia Commonwealth University, Richmond, Virginia.
Patients with advanced colorectal cancer nearing the end of life require a multidisciplinary approach to address the unique challenges they face. Using a case vignette, we outline the various stages of a patient's journey with advanced rectal cancer and the common obstacles to their care as they interface with the medical system. We highlight how Black persons might be vulnerable to differences in screening, treatment, procedural interventions, end-of-life care, and health care decision-making.
View Article and Find Full Text PDFGenome-wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank.
Anaesthesia
December 2024
Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands.
Introduction: Chronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear. This study aimed to identify single-nucleotide polymorphisms associated with developing chronic postsurgical pain after abdominal surgery, one of the most common types of surgery.
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