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| http://dx.doi.org/10.1136/ard.54.8.626 | DOI Listing |
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Autoimmune Type 1 Diabetes: An Early Approach Appraisal for Spain by the AGORA Diabetes Collaborative Group.
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Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing pancreatic beta-cells, leading to lifelong insulin dependence. This review explores the current understanding of T1D pathogenesis, clinical progression, and emerging therapeutic approaches. We examined the complex interplay between genetic predisposition and environmental factors that could trigger the autoimmune response as well as the immunological mechanisms involved in beta-cell destruction.
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Département d'Anatomie et Cytologie pathologiques, Hôpital Menzel Bourguiba, Menzel Bourguiba, Tunisia.
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Applied Computational Ecology Lab, School of Natural Resources, University of Missouri, Columbia, MO, 65211, United States of America. Electronic address:
The destruction and decline of prairie habitats due to landscape repurposing have profoundly impacted the diversity of plant, animal, and insect life. In the Central United States, the reconstruction of prairie habitats from farmland is a widely applied strategy to raise diversity and recreate a healthy, complex ecosystem. In Central Missouri, we examine the consequences of reconstruction efforts on the prevalence of zoonotic diseases and their associated pathogens by performing tick-flagging at two prairie sites.
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Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan. Electronic address:
Objectives: Systemic administration of conditioned medium (CM) from stem cells derived from human exfoliated deciduous teeth (SHED-CM) in mouse models of rheumatoid arthritis, osteoporosis, and osteoarthritis suppresses excessive osteoclast activity and restores bone integrity. However, the mechanism through which SHED-CM regulates osteoclastogenesis remains largely unknown. In the present study, we examined the anti-osteoclastogenic mechanism of SHED-CM in vitro.
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