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Boron in My Mind: A Comprehensive Review of the Evolution of the Diverse Syntheses of 4-Borono-l-Phenylalanine, the Leading Agent for Boron Neutron Capture Therapy.
ChemMedChem
March 2025
University of Windsor, Chemistry and Biochemistry, 401 Sunset Ave., N9B 3P4, Windsor, CANADA.
Boron Neutron Capture Therapy (BNCT) leverages the nuclear reaction between boron-10 and thermal neutrons to selectively destroy cancer cells while minimizing damage to surrounding healthy tissues. This therapy has found use in treating glioblastoma, which as a brain cancer, is difficult to treat using conventional radiotherapy, surgery, and chemotherapy due to location and the risk of brain damage. However, to work, the cells must contain 10B.
View Article and Find Full Text PDFSeizures Associated with Autoimmune Disorders - Current Treatment Approaches.
Semin Neurol
March 2025
Epilepsy Division, Department of Neurology, Mayo Clinic, Rochester, Minnesota.
Autoimmune-associated seizures and epilepsy are increasingly recognized in clinical practice and can arise in the setting of acute encephalitis but in some cases may present with chronic focal epilepsy. These conditions are usually resistant to antiseizure therapy but may respond definitively to timely immunotherapy. Early diagnosis and treatment are critical to minimize neural injury and optimize outcomes.
View Article and Find Full Text PDFBifidobacterium bifidum 1007478 derived indole-3-lactic acid alleviates NASH via an aromatic hydrocarbon receptor-dependent pathway in zebrafish.
Life Sci
March 2025
Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Tsinghua University, Beijing 100084, China. Electronic address:
Aims: This study investigates the potential of Bifidobacterium bifidum 1,007,478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.
Materials And Methods: A zebrafish model of NASH was established by exposure to HFD and fructose. BB478 was administered, and the effects on liver lipid accumulation, oxidative stress, and inflammation were assessed.
Preparation of glass nanofiber-reinforced tricarboxylic cellulose hydrogel immobilized with phosphor nanoparticles for detection of fingerprints and anticounterfeiting applications.
Int J Biol Macromol
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Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Photochromic inks have been a significant certification approach to improve document anticounterfeiting efficiency. However, the weak photostability and poor durability are two of their major shortcomings. Herein, this article details the development of a photochromic and self-healable hydrogel for advanced anticounterfeiting uses.
View Article and Find Full Text PDFDprE1 Inhibitors: An insight into the recent developments and synthetic approaches.
Eur J Pharm Sci
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria; Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address:
In the current medical era, the proliferation and dissemination of drug-resistant strains of Mycobacterium tuberculosis continue to pose a significant worldwide health hazard, necessitating the development of new and innovative medications to combat tuberculosis. Decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) is a crucial enzyme for cell wall synthesis in Mycobacterium tuberculosis (Mtb). Its importance is due to its eminent contribution in forming lipoarabinomannan and arabinogalactan.
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