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Pulsed Ultrasound-Mediated Drug Delivery Enhancement Through Human Sclera.
Transl Vis Sci Technol
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: The purpose of this study was to characterize whether pulsed ultrasound (PUS) affects transscleral drug delivery.
Methods: Fluorescein sodium (NaF, 376 Da) and fluorescein isothiocyanate-conjugated dextran 40 (FD-40, 40 kDa) were used as model drugs. Human sclera grafts were placed in modified Franz diffusion cells and were treated by PUS (1 megahertz [MHz], 0.
[Molecular Mechanism of Protein C Deficiency Caused by Mutations of Gene N355S, G392E, T314A].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Suzhou 215006, Jiangsu Province, China.
Objective: To study the molecular mechanism of functional defect of protein C (PC) caused by point mutations of human protein C gene ( ) N355S , G392E and T314A.
Methods: The wild-type and mutant plasmids (PC, PC, PC, PC) of gene were constructed and transiently transfected into HEK293 cells. The expression of mutant proteins in vitro were tested.
Biological and chemical properties of new multi-functional root canal irrigants.
J Dent
February 2025
Dental College of Georgia, Augusta University, Augusta, GA, USA. Electronic address:
Objectives: To evaluate the efficacy of multi-functional root canal irrigating solutions in the removal of canal wall smear layers, antibacterial activity, cytotoxicity, and tissue dissolution efficacy.
Methods: Forty single-rooted teeth were mechanically instrumented and irrigated with Triton, EndoJuice™, EDTA, and 0.9 % saline.
Unnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries.
J Pediatr Surg
February 2025
Department of Surgery, New Haven, CT 06510, USA; Yale University School of Medicine, New Haven, CT 06510, USA.
Background: The Pediatric Emergency Care Applied Research Network (PECARN) guidelines provide an algorithm to select patients with mild head trauma at highest risk for clinically important traumatic brain injury (ciTBI) in whom computed tomography (CT) would facilitate management. Failure to follow PECARN criteria exposes children to unnecessary radiation and contributes to increasing hospital costs, length of stay, and parental anxiety. We sought to evaluate the subsequent allocation of resources to low and intermediate risk group patients who underwent an initial Head CT - which was not indicated by PECARN guidelines but which identified cranial or intracranial injury.
View Article and Find Full Text PDFA 68-year-old woman presented with worsening dyspnea. She had presented to her local community hospital 10 days earlier with similar symptoms. She was diagnosed with a right-sided pleural effusion, which was attributed to pneumonia and treated with antibiotics.
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