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Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia.
Heliyon
May 2024
Department of Psychiatry, Shiga University of Medical Science, Japan.
Background: Several hypotheses regarding the pathomechanisms of schizophrenia have been proposed. If schizophrenia is a unitary disease, then these pathological processes must be linked; however, if such links do not exist, schizophrenia may best be considered a group of disorders. Only a few studies have examined the relationships among these pathomechanisms.
View Article and Find Full Text PDFSerum Nardilysin as a Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma.
J Clin Med
May 2022
Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu 610041, China.
Background: Nardilysin, (N-arginine dibasic convertase, NRDC) has been reported to play an important role in cancer progression, and is associated with tumor proliferation signals and inflammatory signals, such as tumor necrosis factor-a (TNF-a) and heparin-binding epidermal growth factor-like growth factor (HB-EGF), through the activation of disintegrin and metalloproteinase (ADAM) proteases. NRDC has recently been revealed to be involved in the tumorigenesis of various types of cancer, including intrahepatic cholangiocarcinoma, malignant cerebral infarction, esophageal squamous cell carcinoma, and gastric cancer. However, the expression profiles and biological relevance of NRDC in pancreatic ductal adenocarcinoma have rarely been reported.
View Article and Find Full Text PDFIncreased serum nardilysin is associated with worse long-term outcome of ST-elevation myocardial infarction.
Eur Rev Med Pharmacol Sci
November 2018
Department of Emergency Medicine, First Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Objective: Nardilysin (N-arginine dibasic convertase, NRDC) is a kind of metalloendopeptidase associated with several inflammatory diseases. NRDC is reported to be eligible for early detection of acute coronary syndrome. However, the availability and effectiveness of NRDC in predicting the prognosis of patients with ST-elevation myocardial infarction has never been investigated.
View Article and Find Full Text PDFNardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.
JCI Insight
April 2018
Department of Gastroenterology and Hepatology, and.
Colon cancer is a complex disease affected by a combination of genetic and epigenetic factors. Here we demonstrate that nardilysin (N-arginine dibasic convertase; NRDC), a metalloendopeptidase of the M16 family, regulates intestinal tumorigenesis via its nuclear functions. NRDC is highly expressed in human colorectal cancers.
View Article and Find Full Text PDFInsulin-like growth factor-1 activates different catalytic subunits p110 of PI3K in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17.
Mol Cell Biochem
February 2018
Department of Anatomy, Inje University College of Medicine, 75, Bokji-ro, Busanjin-gu, Busan, zip code: 47392, Republic of Korea.
The activation of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) is critical for the induction of epithelial-mesenchymal transition (EMT) by growth factors, including insulin-like growth factor 1 (IGF-1). The activation of intracellular lipogenesis provides proliferative and survival signals for cancer cells. In this study, we investigated the connection between lipogenesis-related EMT processes and IGF-1-mediated PI3K p110 isoform activation in primary (SW480 cells) and metastatic (SW620) colon carcinoma cells.
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