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The purpose of this study is to describe the prevalence of problematic feeding in the first 6 months of life in infants born preterm, the impact of feeding problems on the family and parent, and explore which factors known at the time of neonatal discharge predict later symptoms of problematic feeding. The study design is a longitudinal, observational study. The sample included 43 infants born at 28.
View Article and Find Full Text PDFResistance to quorum sensing inhibition spreads more slowly during host infection than antibiotic resistance.
Gut Microbes
December 2025
Center for Microbial Ecology and Technology (CMET), Department of Biotechnology, Ghent University, Gent, Belgium.
Antibiotic resistance is a rising problem and new and sustainable strategies to combat bacterial (intestinal) infections are therefore urgently needed. One promising strategy under intense investigation is the inhibition of quorum sensing, bacterial cell-to-cell communication with small molecules. A key question with respect to the application of quorum sensing inhibition is whether it will impose selective pressure for the spread of resistance.
View Article and Find Full Text PDFPeutz-Jeghers Syndrome Presenting With Iron-Deficiency Anaemia and a Giant Colonic Polyp.
Cureus
February 2025
Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.
Peutz-Jeghers syndrome (PJS) is an uncommon autosomal dominant disorder that manifests as mucocutaneous pigmentation and hamartomatous polyps in the gastrointestinal system. Pigmentation of the skin and mucous membranes may be present from birth, but it typically appears in early childhood and can sometimes develop later. In addition to an increased lifelong risk of cancers and problems, such as gastrointestinal bleeding from polyposis, hamartomatous polyps can develop in the stomach, small bowel, or colon.
View Article and Find Full Text PDFInflammatory bowel disease (IBD) is a chronic disorder associated with inflammation in the gastrointestinal tract, leading to a range of debilitating symptoms. Fecal calprotectin is an established biomarker for ulcerative colitis (UC), one of the main IBD diseases, which provides indications of the presence and severity of inflammation in the digestive tract. Enzyme-Linked Immunosorbent Assay (ELISA) as a gold standard approach for fecal calprotectin detection is time-consuming and impractical in point-of-care settings.
View Article and Find Full Text PDFThe Vibrating Capsule: Safety and Tolerability in Patients With Chronic Idiopathic Constipation.
Neurogastroenterol Motil
March 2025
Division of Gastroenterology/Hepatology, Augusta University, Augusta, Georgia.
Background: Chronic idiopathic constipation (CIC) remains a significant problem globally with increasing estimates for disease burden. In a Phase 3 placebo-controlled trial, a novel treatment using the Vibrating Capsule was recently shown to be effective in treating patients with CIC. However, its safety and tolerability has not been described in detail.
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