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Keratoconjunctivitis sicca in intact Aksaray Malakli breed dogs: Evaluation of 50 cases.
Vet Ophthalmol
December 2024
Faculty of Veterinary Medicine, Department of Biostatistics, Ankara University, Ankara, Turkey.
Article Synopsis
- The study focuses on keratoconjunctivitis sicca (KCS), a condition in dogs that leads to eye damage due to reduced tear production, particularly in Aksaray Malakli breed dogs.
- Researchers evaluated fifty healthy dogs showing signs of eye irritation and used tests to measure tear production and film stability.
- Results indicated that dogs with third eyelid gland prolapse had lower tear production and film stability, highlighting a need for further research to manage KCS in this breed.
Elevated Serum Levels of Osteopontin in Patients with Psoriasis: Is It Associated with Ocular Comorbidities?
Dermatol Pract Concept
October 2024
Department of Dermatology and Venereology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Introduction: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population via immune-mediated mechanisms. Osteopontin plays a crucial role in T-helper 1- and T-helper 17-mediated illnesses, including psoriasis. Ocular complications in psoriasis have been reported, and their assessment is of significant importance.
View Article and Find Full Text PDFApplication of OSA-VET and qualiquantitative tear tests in brachycephalic dogs with and without keratoconjunctivitis sicca.
Vet Res Commun
November 2024
Department of Veterinary Surgery, Federal University of Paraná (UFPR), Palotina, Brazil.
The aim was to compare the outcomes acquired from the OSA-Vet device with conventional quantitative and qualitative tear tests and between groups within each test, in brachycephalic dogs both healthy and those diagnosed with keratoconjunctivitis sicca. The dogs were divided into four groups: healthy dogs (HD), with mild KCS (MIKCS); moderate KCS (MOKCS); severe KCS (SKCS). All patients underwent ocular surface diagnostic examination in the following order, with a 10-minute interval between tests: non-invasive tear film breakup time (TBUTNI - OSA-Vet), tear meniscus height (TMH-OSA-Vet), meniscometry (I-Tear test), Schirmer Tear Test-1 (STT-1), and tear film breakup time (TBUT).
View Article and Find Full Text PDFImmune and non-immune mediators in the fibrosis pathogenesis of salivary gland in Sjögren's syndrome.
Front Immunol
October 2024
School of Chinese Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Article Synopsis
- - Sjögren's syndrome (SS) is an autoimmune disease characterized by symptoms like dry eyes and mouth, primarily affecting the lacrimal and salivary glands, leading to irreversible damage known as glandular fibrosis due to chronic inflammation.
- - The exact mechanisms behind glandular fibrosis in SS are not well understood, but it’s believed to involve interactions between immune cells and glandular epithelial cells, along with factors like TGF-β and extracellular matrix remodeling.
- - There is a potential link between viral infections, such as COVID-19, and the worsening of SS symptoms, as viral responses can intensify autoimmune reactions and lead to increased inflammation in the salivary glands.
Overlap of Sjögren's Syndrome and Immune-Mediated Necrotizing Myopathy With Interstitial Lung Disease: A Case Report.
Cureus
September 2024
Department of Respiratory Medicine, Fukuchiyama City Hospital, Kyoto, JPN.
Immune-mediated necrotizing myopathy (IMNM), an inflammatory muscle disease, typically presents as severe muscle weakness due to immunologic mechanisms. Some cases also show cutaneous manifestations, interstitial lung disease, and sicca symptoms. In this report, we present a unique case of an elderly man with a history of mild and stable Sjögren's syndrome (SS) for over 10 years, who later developed interstitial lung disease and myositis, leading to a diagnosis of IMNM confirmed by the presence of anti-signal recognition particle antibodies.
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