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Introduction And Importance: Buerger's disease is an uncommon segmental nonatherosclerotic vasculitis essentially affecting small to medium-sized arteries and veins of upper and lower extremities and can lead to limb amputation. Visceral vessel involvement is quite rare accounting for 2% of cases presenting with acute abdomen due to mesenteric ischemia. Moreover, isolated visceral involvement is even rare.

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Article Synopsis
  • A study assessed the demographics and health conditions of 3,220 patients in Japan with thromboangiitis obliterans (TAO), finding that 87.6% were male and a significant portion were elderly, with 17.0% having undergone amputation.
  • The research indicated that smoking history increased amputation rates, showing a notable difference between smokers and non-smokers (17.7% vs. 13.0%), suggesting that smoking adversely affects patient outcomes.
  • The findings underscore that TAO primarily threatens patients' limbs rather than being life-threatening; thus, comprehensive long-term health support, including smoking cessation and managing related health conditions, is vital for improving patient quality of life.
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Background: Peripheral manifestations secondary to progressive vascular occlusions are characteristic of the rare condition termed thromboangiitis obliternas (TAO) or Buerger's disease. The central manifestations of this disease are however poorly characterized, particularly those of psychiatric nature, and their prevalence is largely unknown. Speculations have been made around the polymorphic nature and triggers of observed psychopathology in TAO; much however remains to be unraveled in this area.

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Secondary fungal infections are a critical problem that accompany immunosuppressive therapy for severe coronavirus disease 2019 (COVID-19). We report a fatal case of COVID-19 with disseminated mucormycosis diagnosed during autopsy. A 58-year-old man with diabetes was hospitalized for severe COVID-19 and treated with remdesivir, systemic steroids and tocilizumab.

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Young-onset dementia (YOD, age at onset below 45 y) has a broad differential diagnosis. We describe a 41-year-old man with atypical manifestations of YOD syndrome in cerebral thromoboangiitis obliterans (CTAO). Extensive antemortem workup including clinical assessment, laboratory investigations, neuroimaging, and genetic testing did not elucidate a diagnosis.

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