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Neural therapy in notalgia paresthetica.

Arch Dermatol Res

November 2024

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Article Synopsis
  • - Notalgia Paresthetica (NP) is a chronic nerve condition causing itching, pain, and unusual sensations, and it is often underdiagnosed without standard treatment options.
  • - A study evaluated neural therapy on 12 NP patients aged 30-60 over five sessions, measuring outcomes like pain and quality of life using various scales before and after treatment.
  • - Results showed significant improvements in pain, neuropathic symptoms, and overall well-being, indicating that neural therapy could be an effective complementary treatment for NP.
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Article Synopsis
  • * It often manifests in specific forms such as brachioradial pruritus in the forearms, notalgia paresthetica in the upper back, and anogenital itch, which can be related to spine problems.
  • * Treatment may involve topical remedies or systemic medications, but currently, there are no FDA-approved options specifically for neuropathic itch, making it essential to understand its neural causes for effective management.
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Article Synopsis
  • This review focuses on the relationship between pathogenic variants related to medullary thyroid cancer (MTC) and multiple endocrine neoplasia type 2 (MEN2), especially considering their connection to cutaneous lichen amyloidosis (CLA).
  • It highlights that most MEN2A patients with CLA have a specific pathogenic variant at codon 634, yet the connection between CLA and MTC remains poorly understood despite being recognized for over thirty years.
  • The findings indicate that CLA usually appears early in life, often before MTC is diagnosed, and the relationship between mutations and CLA presentation can vary even within the same family.
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