AI Article Synopsis
- The study measured platelet-activating factor (PAF) levels in plasma and neutrophils of 74 patients with active pulmonary tuberculosis, comparing them to 12 healthy volunteers.
- Higher plasma PAF levels were found in about half of the patients, especially those newly diagnosed or with severe lung damage, and it was significantly elevated in their neutrophils compared to healthy individuals.
- Incubation with killed BCG culture did not affect PAF levels in healthy neutrophils but increased variability among tuberculosis patients, leading to a threefold higher concentration of PAF in their stimulated neutrophil incubation media.
Article Abstract
The content of platelet-activating factor (PAF) in plasma, blood, native neutrophils, in the same neutrophils after their incubation with a killed BGC culture and in the incubation medium was measured in 74 patients with various types of active pulmonary tuberculosis. Twelve healthy volunteers formed a control group. PAF was measured by the rabbit platelet aggregation technique. Higher plasma PAF levels were found in half the patients. The highest plasma PAF concentration was observed in the newly revealed patients, in cases with forming cavities in the lung tissue, in those discharged a lot of sputum Mycobacterium tuberculosis, and in those with lymphopenia. PAF content in the native neutrophils of patients was 10 times as high as that in healthy persons. Incubation with the killed BCG culture had no influence on PAF content in the control neutrophils, but greatly increased individual differences in patients. The concentration of PAF in the incubation media of stimulated neutrophils from tuberculosis patients was 3 times higher than in the controls.
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