AI Article Synopsis
- BALB/c mice underwent a training session for a bar-pressing task and received either saline or apamin injections afterward.
- In a retention test conducted at varying intervals (25, 85, or 180 minutes), the saline group showed a decrease in performance at the 85-minute mark, demonstrating a Kamin-like effect.
- Conversely, the apamin-injected mice performed better during the same interval, suggesting that apamin may enhance the processes involved in memory consolidation and long-term storage.
Article Abstract
BALB/c mice were trained in a partial acquisition session of an appetitive bar-pressing task. They then received an immediate post-acquisition i.p. injection of either saline or apamin 0.2 mg kg-1. Each group was submitted to a retention test that was delayed either 25, 85 or 180 min after initial acquisition. In saline-injected groups retention of the original training was a U-shaped function of intersession interval with a significant drop in performance (Kamin-like effect) at the 85 min time interval. In contrast, at this same time, apamin injected subjects made significantly more reinforced responses than control animals. The suppression of the Kamin-like effect by apamin could be a consequence of an acceleration of the neuronal mechanisms implicated in consolidation and long-term memory storage processes.
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| http://dx.doi.org/10.1097/00001756-199506090-00016 | DOI Listing |
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Article Synopsis
- BALB/c mice underwent a training session for a bar-pressing task and received either saline or apamin injections afterward.
- In a retention test conducted at varying intervals (25, 85, or 180 minutes), the saline group showed a decrease in performance at the 85-minute mark, demonstrating a Kamin-like effect.
- Conversely, the apamin-injected mice performed better during the same interval, suggesting that apamin may enhance the processes involved in memory consolidation and long-term storage.
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