The serologic structure of Lac+ recombinants of 2a, 2b, 5a and var. Y serotypes of Sh. flexneri was compared. Rec. 2a Lac+, rec. 2b Lac+ and rec. Y Lac+ were shown to be identified, and rec. 5a Lac+ was found to differ from those mentioned in that it was deficient in determinants for 3,4 group antigen complex. Furthermore, the paper discusses the presumable genetic mechanisms of the described variability.
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Phys Eng Sci Med
December 2024
Department of Medical Physics and Biomedical Engineering School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
The current study aimed to predict lymphovascular invasion (LVI) using multiple machine learning algorithms and multi-segmentation positron emission tomography (PET) radiomics in non-small cell lung cancer (NSCLC) patients, offering new avenues for personalized treatment strategies and improving patient outcomes. One hundred and twenty-six patients with NSCLC were enrolled in this study. Various automated and semi-automated PET image segmentation methods were applied, including Local Active Contour (LAC), Fuzzy-C-mean (FCM), K-means (KM), Watershed, Region Growing (RG), and Iterative thresholding (IT) with different percentages of the threshold.
View Article and Find Full Text PDFJ Cell Biol
July 2018
Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
Chromosomal replication is the major source of spontaneous DNA double-strand breaks (DSBs) in living cells. Repair of these DSBs is essential for cell viability, and accuracy of repair is critical to avoid chromosomal rearrangements. Repair of replication-dependent DSBs occurs primarily by homologous recombination with a sister chromosome.
View Article and Find Full Text PDFACS Synth Biol
April 2017
Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Chromosomal integration offers a selection-free alternative to DNA plasmids for expression of foreign proteins and metabolic pathways. Episomal plasmid DNA is convenient but has drawbacks including increased metabolic burden and the requirement for selection in the form of antibiotics. E.
View Article and Find Full Text PDFPLoS One
September 2016
School of Health and Sports Sciences, University of the Sunshine Coast, Sippy Downs, QLD, Australia.
Purpose: High intensity interval training (HIIT) has been proposed as a time-efficient format of exercise to reduce the chronic disease burden associated with sedentary behaviour. Changes in oxygen utilisation at the local tissue level during an acute session of HIIT could be the primary stimulus for the health benefits associated with this format of exercise. The recovery periods of HIIT effect the physiological responses that occur during the session.
View Article and Find Full Text PDFPLoS One
July 2016
Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato, Gto. 36050, México.
The expression of and role played by RecA in protecting sporulating cells of Bacillus subtilis from DNA damage has been determined. Results showed that the DNA-alkylating agent Mitomycin-C (M-C) activated expression of a PrecA-gfpmut3a fusion in both sporulating cells' mother cell and forespore compartments. The expression levels of a recA-lacZ fusion were significantly lower in sporulating than in growing cells.
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