The interaction of specific immunoglobulins G to the histone H1 with the thymocytes of intact animals has been demonstrated to increase the reception of acridine orange (AO) in nuclear chromatin. This raises the rate of AO fluorescence and lowers the level of light polarization. This may result from occurring decondensation processes. On the other hand, the interaction of antihistone antibodies with irradiated rat thymocytes causes no changes in the package of nuclear chromatin, which is likely to be due to destructive processes which take place in the cells in response to radiation. The immunoglobulins G to the core histone H2B produce an insignificant effect on the condensation rate of the nuclear material of thymocytes both from intact and irradiated animals.
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