The authors report the use of a vascular island nasolabial flap with facial arterial pedicle and reverse blood flow inspired by the flap described by C. Le Quang in an unpublished indication. This case concerns a 64-year-old patient with a large botryomycoma of the columella. The size of the defect following excision and the length of the columella authorized reconstruction using a split thickness nasolabial reverse flap. At one year post-operatively the result was aesthetic and defatting was unnecessary. This flap is used to repair defects of the nasal lateral wall and ala. In some conditions, it can be used to repair the collumela, providing a safe vascular support in one stage.
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Allergol Immunopathol (Madr)
January 2025
Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zheiiang, China.
To illustrate the potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in mitigating septic lung injury by reducing the excessive formation of neutrophil extracellular traps (NETs), a mouse model of septic lung injury was induced through cecal ligation and puncture (CLP). The mice received intraperitoneal injections of MSC-Exos. Post injection, pathological alterations of the lung tissue were evaluated through HE staining, and the levels of inflammatory markers in each mouse group at various time points were assessed using ELISA kits.
View Article and Find Full Text PDFEur J Epidemiol
January 2025
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St., Suite 100, Richmond, VA, 23298, USA.
Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which may underpin some of the adverse health sequelae of smoking. However, prior causal analyses with Mendelian Randomisation (MR) have found limited support for such effects.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Huntington Medical Research Institutes, Pasadena, CA, USA.
Background: Dicarboxylic acids (DCAs) are critically important for intermediate metabolism. Since mitochondrial dysfunction and energy dysregulation are associated with AD pathology, we hypothesize that fluctuations in plasma DCAs would accompany AD pathology.
Method: In an ongoing brain-aging study, we recruited older adults (>65 years) classified as cognitively healthy (CH) after neuropsychological testing.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory loss, and impaired daily functioning. As the global population ages, the prevalence of AD continues to rise, emphasising the urgent need for effective preventive and therapeutic strategies. Carotenoids, a group of naturally occurring pigments with antioxidant properties, have gained attention for their potential neuroprotective effects.
View Article and Find Full Text PDFBackground: Cerebral amyloid angiopathy (CAA) has been recognized as one of the morphologic hallmarks of Alzheimer disease (AD). The development of new AD drugs has brought unforeseen challenges that manifest as amyloid-related imaging abnormalities (ARIA) appearing as vasogenic edema/effusion (ARIA-E) and cerebral microhemorrhage/hemosiderosis (ARIA-H). The prominence of CAA pathology in aged squirrel monkeys (SQMs), a New World non-human primate model, underlines the importance of advancing this unique species for use in AD and dementia research.
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