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Improved biosynthesis of tyrosol by epigenetic modification-based regulation and metabolic engineering in Saccharomyces cerevisiae.
J Biotechnol
December 2024
Featured Laboratory for Biosynthesis and Target Discovery of Active Components of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Binzhou Medical University, Yantai 264003, PR China. Electronic address:
Article Synopsis
- Aromatic amino acids, like tyrosol, are important for industries such as food and pharmaceuticals, but current production methods have limitations.
- The study explored how to boost tyrosol production using epigenetic modifications and optimizing its biosynthetic pathway.
- Key modifications included overexpressing specific genes, deleting others, and ultimately developing a strain that produced significantly more tyrosol (954.69 mg/L), marking a 61.7-fold increase in yield.
Decoding the Nucleolar Role in Meiotic Recombination and Cell Cycle Control: Insights into Cdc14 Function.
Int J Mol Sci
November 2024
Instituto de Biología Funcional y Genómica, IBFG, CSIC-USAL, 37007 Salamanca, Spain.
The cell cycle, essential for growth, reproduction, and genetic stability, is regulated by a complex network of cyclins, Cyclin-Dependent Kinases (CDKs), phosphatases, and checkpoints that ensure accurate cell division. CDKs and phosphatases are crucial for controlling cell cycle progression, with CDKs promoting it and phosphatases counteracting their activity to maintain balance. The nucleolus, as a biomolecular condensate, plays a key regulatory role by serving as a hub for ribosome biogenesis and the sequestration and release of various cell cycle regulators.
View Article and Find Full Text PDFHeat of reaction in individual metabolic pathways of yeast determined by mechanistic modeling in an insulated bioreactor.
Biotechnol Biofuels Bioprod
November 2024
Université Paris-Saclay, CentraleSupélec, Laboratoire de Génie des Procédés et Matériaux, Centre Européen de Biotechnologie et de Bioéconomie (CEBB), 3 rue des Rouges Terres, Pomacle, 51110, France.
Background: The yeast Saccharomyces cerevisiae, commonly used in industry, exhibits complex metabolism due to the Crabtree effect, fermenting alcohol even under aerobic conditions when glucose exceeds 0.10-0.15 g/L.
View Article and Find Full Text PDFFine-tuning stress responses by auxiliary feedback loops that sense damage repair.
J Cell Biol
December 2024
Institute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Bonn, Bonn, Germany.
Mogk and den Brave discuss exciting results from a comprehensive screen of heat shock response components in yeast, published in this issue by Pincus and colleagues (https://doi.org/10.1083/jcb.
View Article and Find Full Text PDFExploiting phenotypic heterogeneity to improve production of glutathione by yeast.
Microb Cell Fact
October 2024
School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Article Synopsis
- Gene expression noise in yeast can lead to a mix of high- and low-producing cells, limiting overall metabolite production, which prompted this study to explore ways to enhance glutathione (GSH) output.
- Researchers engineered a counter-selection system in yeast that uses feedback inhibition to target low GSH-producing cells by linking GSH1 gene expression with a counter-selectable marker.
- This approach resulted in an 18% increase in mean GSH levels while ensuring the selected high-producing phenotype was non-heritable, demonstrating the potential to improve metabolite production by favoring high-performing cells in mixed populations.
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