A simple way to evaluate the rectal sensorial threshold has been the sloped distention of a rectal balloon, as a way to obtain the required volume to induce desire to defecate (VDE) and pain (VTM). Six medical groups belonging to the Argentine Motility Circle, studied in 14 patients (7M, 7F age 51 +/- 10.1) the VDE and VTM. The measurements were repeated in the same subjects with intervals longer than 24 Hs. The estimate of precision established a coefficient of variation (CV) for VDE of 10.23% (2CV = 20.46%). And so Reproducibility was found to be not acceptable. The CV for VMT was 1.44 (2CV = 2.88%) this could be considered a very good reproducibility. In conclusion, the VTM appears to be a reproducible measurement suitable for clinical and pharmacological studies of the rectal sensorial perception.
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J Transl Med
January 2025
Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, P.R. China.
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Nantes University, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France.
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Division of Neurogastroenterology/Motility, Medical College of Georgia, Augusta University, Augusta, Georgia.
Anorectal neuropathy causes anorectal dysfunction, yet it is poorly recognized. This stems from both a lack of understanding of the extrinsic and intrinsic innervation of the anorectum and tools for evaluation of neuronal function. Our objective was to provide an improved understanding of the neuronal networks of the anorectum and discuss its functional significance.
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