During the period of 6 years 176 patients with an acute pancreatitis were treated in the clinic, 17 (9,1%) of whom with destructive forms of disease. Tactics of treatment was developed on the grounds of ultrasonographic scanning of pancreas data, laparoscopy and enzymologic investigation results. Twenty two (12,5%) of patients were operated on. Postoperative lethality was 22,7%. Erosive hemorrhage was the cause of death in 2 patients and septic-purulent complications--in 3.
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Psychiatr Serv
January 2025
Department of Psychiatry, University of California San Diego, La Jolla.
Objective: The use of court-ordered mental health treatment through programs such as assisted outpatient treatment (AOT) carries substantial ramifications for the welfare of individuals with serious mental health conditions.
Methods: In this review, the authors used a narrative methodology and performed an interpretive synthesis of existing U.S.
Chemistry
January 2025
Florida State University, Chemistry and Biochemistry, 95 Chieftan Way, 32306, Tallahassee, UNITED STATES OF AMERICA.
Since antiquity, alkaloid natural products have served as medicinal ingredients that still contribute as an inspiration for the development of novel therapeutics. For the synthetic chemist, much of the importance of natural products lies in their acting as a forcing-function for the invention of new synthetic strategies and tactics for molecular assembly. With this rich history in mind, it remains an important goal for chemists to build nitrogenous structures with greater efficiency, abiding by economies of synthesis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Erasmus University Rotterdam, Rotterdam, Netherlands.
Background: 'Intellectual assets' generated in traditional university settings, that may not fit the interests of the standard 'valuation criteria' (i.e. commercially profitable), such as non-pharmacological dementia care research, often remain siloed within their respective research disciplines and originating institutions.
View Article and Find Full Text PDFCurr Top Med Chem
January 2025
Integrated Drug Discovery Centre, Department of Pharmaceutical Chemistry, Acharya & BM Reddy College of Pharmacy, Bengaluru 560107, Karnataka, India.
Despite ongoing advancements in drug design and developments, breast cancer remains a serious and devastating disease and is ranked as the second most common illness in women. Breast cancer rates have increased significantly during the last 40 years. This necessitates the development of novel treatment techniques.
View Article and Find Full Text PDFJ Econ Entomol
January 2025
Department of Entomology and Plant Pathology and the North Carolina Plant Sciences Institute, NC State University, Raleigh, NC, USA.
Debate over resistance management tactics for genetically engineered (GE) crops expressing insecticidal toxins is not new. For several decades, researchers, regulators, and agricultural industry scientists have developed strategies to limit the evolution of resistance in populations of lepidopteran and coleopteran pests. A key attribute of many of these events was insecticide resistance management (IRM) strategies designed around a presumed high-dose expression sufficient to kill 99.
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