A new rat mutant with abnormal behavior has been found in a closed colony of Slc: SD. The affected rats turned around after their own tails beginning 4-5 weeks after birth, in response to extroceptive stimuli, such as sound or vibration. The behavior was more pronounced in younger animals. On gross observation, no alteration was found in the cerebrum, cerebellum, or anterior, posterior, or lateral semicircular canals. Light microscopic examination revealed no abnormality in the cerebrum or cerebellum. The trait was controlled by an autosomal dominant gene with incomplete penetrance (78.0%) when transferred to the WKY genetic strain background. It was named "turning" with the gene symbol Tur. A congenic strain was established, which was designated WKY/Eis-Tur.
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http://dx.doi.org/10.1093/oxfordjournals.jhered.a111591 | DOI Listing |
BMC Musculoskelet Disord
January 2025
Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Tianhe District, Guangzhou, Guangdong Province, China.
Lower back pain comprises the majority of the disease burden of patients with ankylosing spondylitis (AS), while the alterations of the large-scale brain networks could be implicated in the neuropathophysiology of pain. The frontoparietal network (FPN) is known as a pain modulation hub, with key nodes dorsolateral prefrontal cortex (dlPFC) and ventrolateral prefrontal cortex (vlPFC) participating in the pain modulation and reappraisal process. In this study, we adopted the analytical approaches of independent component analysis (ICA) and seed-based correlation analysis (SCA) to examine the resting-state functional connectivity (rsFC) of the large-scale brain networks, notably FPN, between 82 AS patients and 61 healthy controls (HCs).
View Article and Find Full Text PDFBrain Behav
January 2025
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences (CAS), Beijing, the People's Republic of China.
Background: Psychotherapeutic memory plays an important role in maintaining therapeutic effects; however, the neural mechanisms of therapeutic metaphor promoting long-term memory were still unknown.
Objective: This study used metaphorical micro-counseling dialog scenarios to investigate the memory effect of therapeutic metaphor and correlated neural mechanisms.
Methods: At first, 31 participants read a mental distress problem, followed by a metaphorical or a literal solution, while undergoing functional magnetic resonance imaging scanning during the encoding phase.
Hereditary spastic paraplegia (HSP) encompasses a group of rare genetic diseases primarily affecting motor neurons. Among these, spastic paraplegia type 11 (SPG11) represents a complex form of HSP caused by deleterious variants in the SPG11 gene, which encodes the spatacsin protein. Previous studies have described several potential roles for spatacsin, including its involvement in lysosome and autophagy mechanisms, neuronal and neurites development or mitochondria function.
View Article and Find Full Text PDFWorld J Biol Psychiatry
February 2025
Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Objective: Facial emotion recognition is central to successful social interaction. People with autism spectrum disorder (ASD) have difficulties in this area. However, neuroimaging evidence on facial emotion processing in ASD has been diverse.
View Article and Find Full Text PDFTunis Med
January 2025
Department of embryo-fetopathology, La Rabta Maternity and Neonatology Center, El Manar II University, 1007 Tunis, Tunisia.
Introduction: Anencephaly is a serious developmental defect of the central nervous system in which the brain and cranial vault are grossly malformed. The cerebrum and cerebellum are reduced or absent, but the hindbrain is present. Anencephaly is a part of the neural tube defect spectrum.
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