The survey includes data concerning structural proteins of coronaviruses obtained for the last ten years. It elucidates such problems as the proteins organization in the virion, heterogeneity of their composition, structure and biological properties, antigenic and immunobiological properties, prospects of creation of specific immunogenic anticoronavirus, prophylactic and diagnostic preparations.
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Fish Shellfish Immunol
January 2025
Immunology & Vaccinology Group. Centro de Investigaciones Biológicas del Noroeste, S.C. (CIBNOR), Av. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, B.C.S, 23096 , La Paz, Mexico. Electronic address:
Fish aquaculture has increased but also disease problems related to it, along with antimicrobial resistance. The use of medicinal plants containing phytochemicals with antimicrobial, antioxidant, and immunomodulatory activities has been proposed. In this study, C.
View Article and Find Full Text PDFViruses
September 2024
Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Orthoflaviviruses are arthropod-borne viruses that are transmitted by mosquitoes or ticks and cause a range of significant human diseases. Among the most important tick-borne orthoflaviviruses (TBFVs) is tick-borne encephalitis virus (TBEV), which is endemic in Eurasia, and Powassan virus, which is endemic in Asia and North America. There is a significant controversy regarding species assignment in the tick-borne encephalitis virus complex due to the complex phylogenetic, serological, ecological, and pathogenetic properties of viruses.
View Article and Find Full Text PDFVaccines (Basel)
August 2024
Institute of Technology in Immunobiologicals, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.
The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), began in 2019. One of the strategies for pandemic control was mass vaccination. In Brazil, the recombinant COVID-19 vaccine (RCV) was produced on a large scale and offered at no charge to the population.
View Article and Find Full Text PDFChem Biodivers
September 2024
Dept. of Glycochemistry, Lab. Sugars & Glycomimics, Center for Glycomics, Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, SK-84538, Bratislava, Slovakia.
Immunobiological activity of selected decyl and (thio)dodecyl hexopyranosides based on d-glucose, d-galactose, N-acetyl d-glucosamine and d-mannose and their effect on leukemia cell lines L1210 and HL-60 and Candida's biofilm were studied. Alkyl d-glucosides and d-galactosides showed mainly similar antiproliferative properties on leukemia cell lines, while N-acetyl d-glucosaminides revealed diverse properties with lower efficacy. Also, the cytokine response of RAW 264.
View Article and Find Full Text PDFJ Med Biogr
September 2024
Emeritus John P. McGovern Chair in Oslerian Education, The University of Texas Medical Branch, Galveston, TX, USA.
The understanding of the immunobiology of human milk is primarily a 20th-century phenomenon, but, even with our contemporary understanding, it remains a bit of a mystery. Breastfeeding of human milk, although the most obvious and natural form of nutrition for human infants, has been hindered by cultural and societal norms since ancient times. Thus, not all infants have experienced the advantages this form of nutrition may offer.
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