AI Article Synopsis
- The study examined how Saiko-ka-ryukotsu-borei-to (SRBT) affects stress-induced increases in serum corticosterone levels in mice under different stress conditions.
- The results showed that SRBT significantly reduced corticosterone levels in psychological stress models (like conditioned-fear) in a dose-dependent manner, but did not have the same effect in physical stress models (like immobilization and forced swimming).
- This suggests that SRBT is more effective in managing stress related to emotional factors rather than those stemming from physical stress.
Article Abstract
The effect of Saiko-ka-ryukotsu-borei-to (SRBT) on the stress-induced enhancement of serum corticosterone in various stress models was investigated in mice. The serum corticosterone was elevated significantly by immobilized stress, forced-swim stress, electric-shock stress, psychological stress and conditioned-fear stress, respectively. The concentration in the last two models was decreased in a dose-dependent manner by pre-administration of SRBT (10, 60, 100, 600 and 1000 mg/kg, p.o.). Therefore, this action seems to be effective in stress involving emotional factors but ineffective in physical stress models. These results indicate that the anti-stress effect of SRBT is dependent strongly on the degree of psychological change compared with physical change in mice.
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| http://dx.doi.org/10.1248/bpb.18.563 | DOI Listing |
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