Experimental and clinical data on the employment of assisted circulation with extracorporeal oxygenation of the blood, exchange replacement of the blood in high volumes, hemoperfusion, and hyperbaric therapy in the treatment of exotoxic shock caused by methemoglobin-forming and corrosive poisons demonstrate a high efficacy of assisted circulation in the normalization of central hemodynamics (which permits exchange replacement of the blood and hemoperfusion), of the hepatorenal function, hemostasis, and other parameters of the internal media in humans and animals. The method is recommended for wide use at large reanimation and toxicological centers.
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Folia Med (Plovdiv)
December 2021
Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University, Varna, Bulgaria, Varna, Bulgaria.
Introduction: Lipid emulsions are increasingly used as an antidote to lipophilic drug intoxications. The dose recommended by the American Society of Regional Anesthesia is used primarily for the treatment of local anesthetic systemic toxicity. There is insufficient information about what the dose of lipid emulsions (LE) should be in other intoxications depending on their severity.
View Article and Find Full Text PDFEfficacy of reamberin infusion therapy was estimated in 38 patients with severe acetic acid intoxication. Reamberin was shown to have positive effect on certain end-points of the treatment, viz. caused a 2-fold decrease in duration of exotoxic shock (which allowed to use smaller volumes of infusion solutions), 3-fold decrease in the frequency of pneumonia, 5-fold reduction in the frequency of delirium and acute renal insufficiency in the early post-traumatic period.
View Article and Find Full Text PDFThe study of the effects of hemodialysis on the course and outcomes of severe acetic acid (AA) poisoning has shown that use of hemodialysis leads to a significant reduction of lethality (from 78.2 to 46.9%), lethality in acute renal failure (by 20%), of the number of patients who died of exotoxic shock within 24 hours after the poisoning (from 71 to 60%).
View Article and Find Full Text PDFAnesteziol Reanimatol
March 1999
Oxygen regimen of the organism was experimentally studied at the stages of oxygen entry, transport, and consumption in severe exotoxigenic shock caused by poisoning with methemoglobin-forming toxin during correction of this state by different intensive care methods. Analysis of the time course of the basic values of oxygen regimen demonstrated a high efficacy of assisted circulation with extracorporeal oxygenation of the blood and hyperbaric oxygenation in a complex of intensive care methods in such patients.
View Article and Find Full Text PDFMorfologiia
May 1998
Interlaboratory Group of Scientific Research Institute of Military Medicine, Ministry of Defense of Russian Federation.
By method of scanning electron microscopy erythrocyte structure was studied in rats in carbophos poisoning. Following up to 76% acetylcholinesterase inhibition with distinct symptoms of intoxication nearly 30% of erythrocytes were deformed and tended to aggregate. Observation of blood circulation in vessels of pia mater revealed formation of erythrocyte conglomerations in vascular bed.
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