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Plasma tissue plasminogen activator-inhibitor complex levels in acute myocardial infarction patients: an observational study.
BMC Cardiovasc Disord
December 2024
Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Introduction: The activation of the plasmatic coagulation system is a significant contributor to acute myocardial infarction (AMI). This study aimed to investigate the association between the levels of tissue plasminogen activator-inhibitor complex (t-PAIC), thrombin-antithrombin complex (TAT), plasmin-α2 plasmin-inhibitor complex (PIC), and thrombomodulin (TM) with clinical outcomes in patients with AMI.
Methods: Blood samples were collected from 368 patients presenting with acute myocardial infarction in the emergency department to assess levels of t-PAIC, TAT, PIC, and TM.
PROGNOSTIC MARKERS FOR THROMBOTIC EVENTS IN PATIENTS WITH GASTRIC OR COLORECTAL ADENOCARCINOMAS.
Arq Bras Cir Dig
December 2024
Universidade Federal do Rio de Janeiro, Department of Surgery - Rio de Janeiro (RJ), Brazil.
Background: The relationship between thrombosis and cancer is based on evidence that cancer promotes prothrombotic changes in the host hemostatic system. The activation of blood coagulation is closely linked to tumor growth and dissemination.
Aims: To evaluate whether quantifications of plasma circulation tumor deoxyribonucleic acid (DNA) and thrombin-antithrombin complex could act as predictors for thrombotic events and death in patients with gastric or colorectal adenocarcinomas, while also evaluating the Karnofsky Performance Status.
Development of a thrombin-antithrombin complex detection kit and study in venous thromboembolism complicated by cervical cancer.
BMC Biotechnol
December 2024
Department of Laboratory Medicine, Jiangnan University Hospital, Jiangsu Province, 1000 Hefeng Road, Wuxi City, 214122, No, China.
Objective: Our study successfully developed an assay kit for thrombin-antithrombin complex (TAT) and demonstrated the predictive value of plasma TAT concentration in the development of venous thromboembolism (VTE) in patients with cervical cancer.
Method: A retrospective analysis was conducted on 177 patients with cervical cancer who received treatment at the Affiliated Hospital of Jiangnan University in Wuxi City from July 1, 2023 to October 1, 2023. This study provides a comprehensive analysis of cervical cancer patients and their VTE risk factors.
Identification of plasma proteins binding oxidized phospholipids using pull-down proteomics and OxLDL masking assay.
J Lipid Res
November 2024
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria. Electronic address:
Article Synopsis
- Oxidized phospholipids (OxPLs) are recognized as harmful substances that promote inflammation, highlighting the need to understand how they can be detoxified by various plasma proteins.
- Researchers conducted pull-down-proteomic analysis to identify around 150 non-immunoglobulin proteins that specifically bind to oxidized phospholipids, particularly OxPAPC.
- The study confirmed that these proteins, alongside known oxidized phospholipid-binding proteins, can effectively mask OxPLs, potentially influencing their recognition by the immune system.
Comparing the Effect of DOAC-Stop and DOAC-Remove on Apixaban, Rivaroxaban and Dabigatran Prior to Thrombophilia and Lupus Testing.
Br J Biomed Sci
November 2024
Department of Haematology, Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom.
Background: Direct oral anticoagulants (DOACs) interfere with coagulation assays potentially leading to inaccurate results. This study determined the effectiveness of DOAC-stop® and DOAC-remove® in overcoming DOAC interference. It aimed to investigate the extent to which apixaban, rivaroxaban, and dabigatran had an effect on thrombophilia and lupus tests using normal plasma, as well as whether DOACs interfere with true-positive results by testing abnormal controls.
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