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Low grade appendiceal mucinous neoplasm mimicking malignant ovarian tumor: A case report.
Int J Surg Case Rep
December 2024
University of Gondar College of Medicine and Health Sciences, Ethiopia.
Introduction: Mucinous appendiceal neoplasms are unique tumors in which >50 % of the tumor volume is composed of extracellular mucin. They may present as an unruptured mucin-filled appendix or, more commonly, with peritoneal metastases after rupture or transmural invasion of the primary tumor. This case report describes a case of presumed ovarian malignancy with final pathologic diagnosis of low grade appendiceal mucinous neoplasm.
View Article and Find Full Text PDFChallenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer.
Curr Oncol
December 2024
Hudson Institute of Medical Research, Clayton 3168, Australia.
Precision medicine has revolutionised targeted cancer treatments; however, its implementation in ovarian cancer remains challenging. Diverse tumour biology and extensive heterogeneity in ovarian cancer can limit the translatability of genetic profiling and contribute to a lack of biomarkers of treatment response. This review addresses the barriers in precision medicine for ovarian cancer, including obtaining adequate and representative tissue samples for analysis, developing functional and standardised screening methods, and navigating data infrastructure and management.
View Article and Find Full Text PDFAccelerated ovarian failure results in brain alterations related to Alzheimer's disease that are not recovered by high-intensity interval training in mice.
Alzheimers Dement
December 2024
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
Introduction: The menopausal decline in ovarian estrogen production is thought to increase the risk of Alzheimer's disease; however, this link requires further investigation. The chronological development of this connection is not well defined because of the lack of animal models that recapitulate the time course of menopause. This study characterized the cognitive and neuronal effects of the 4-vinylcyclohexene diepoxide (VCD) model of ovarian failure in female mice and assessed whether high-intensity interval training (HIIT) would attenuate impairments.
View Article and Find Full Text PDFBerberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice.
Mol Med
December 2024
Reproductive Medicine Center, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, 528300, China.
Background: Primordial follicle activation is vital for the reproduction of women with advanced age and premature ovarian insufficiency (POI). But there is a lack of effective and safe therapeutic options to activate their primordial follicles in vivo. Berberine (BBR) possesses multiple pharmacological properties, but its impact on primordial follicle activation remains unclear.
View Article and Find Full Text PDFHigh-adhesion ovarian cancer cell resistance to ferroptosis: The activation of NRF2/FSP1 pathway by junctional adhesion molecule JAM3.
Free Radic Biol Med
December 2024
Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450000, China. Electronic address:
Ovarian cancer remains a significant challenge due to the lack of effective treatment and the resistance to conventional therapies. Ferroptosis, a form of regulated cell death characterized by iron-depend and lipid peroxidation, has emerged as a potential therapeutic target in cancer. Ovarian cancer has been reported to exert an "iron addiction" phenotype which makes it is susceptible to ferroptosis inducers.
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