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Danshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps.
Phytomedicine
January 2025
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China,; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China, ; The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Background: The significant distal necrosis of the random-pattern skin flaps greatly restricts their clinical applications in flap transplantation. Previous studies have demonstrated the potential of danshensu (DSS) to alleviate ischemic tissue injury. However, no research to date has confirmed whether DSS can improve the survival of ischemic flaps.
View Article and Find Full Text PDFUse of vascular access methods for hemodialysis in Serbia: Results from SerbVasc registry.
J Vasc Access
January 2025
Clinic for Vascular and Endovascular Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Introduction: In many countries, hemodialysis is still the most common method of renal replacement. Significant regional variations exist in creating and maintaining vascular access for hemodialysis. Therefore, analyzing national registries with vascular access data is essential for developing effective national treatment strategies.
View Article and Find Full Text PDFCursorial ecomorphology and temporal patterns in theropod dinosaur evolution during the mid-Cretaceous.
R Soc Open Sci
January 2025
Hokkaido University Museum, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810, Japan.
Coelurosauria, including modern birds, represents a successful group of theropod dinosaurs that established a high taxonomic diversity and significant morphological modifications. In the evolutionary history of this group, a specialized foot morphology, the arctometatarsus, evolved independently in several lineages and has been considered an adaptation for cursoriality. While its functional significance has been extensively studied, the temporal pattern of this parallel evolution, as well as its origin and influencing factors, remains largely unresolved.
View Article and Find Full Text PDFImpact of different glycoprotein IIb/IIIa inhibitor infusion routes on infarct size and microvascular obstruction in patients with high thrombotic risk ST elevation myocardial infarction.
Acta Cardiol
January 2025
Division of Cardiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Objective: Current guidelines recommend the use of glycoprotein IIb/IIIa (GpIIb/IIIa) inhibitors in patients with ST-segment elevation myocardial infarction (STEMI) only as a bail-out therapy. However, drug penetration to the jeopardised area may not be achieved due to impeded blood flow and increased microvascular resistance. Aim of our study is to investigate the impact of distal intracoronary GpIIb/IIIa inhibitor agent infusion in STEMI patients.
View Article and Find Full Text PDFPre-Fusion Shape Changes of Humeral Metaphyseal Surfaces: A New Method for Assessing Maturity and Age in Non-Adult Skeletal Individuals.
Am J Biol Anthropol
January 2025
Laboratorio de Evolución Humana, Universidad de Burgos. Edificio I+D+i/CIBA, Burgos, Spain.
Objectives: The current research delves into the use of 3D geometric morphometric for assessing shifts in maturity within both the proximal and distal humeral metaphyses. It mainly focuses on establishing correlations between these shifts and the shape changes observed in the corresponding epiphyses established through radiographic imaging.
Material And Methods: The total sample comprises 120 right-side proximal humeral metaphyses and 91 right-side distal humeral metaphyses.
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