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Mechanisms of Neurosyphilis-Induced Dementia: Insights into Pathophysiology.
Neurol Int
December 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Miami Miller, Miami, FL 33136, USA.
Neurosyphilis-induced dementia represents a severe manifestation of tertiary syphilis, characterized by cognitive and neuropsychiatric impairments. This condition arises from the progression of syphilis to the central nervous system, where the spirochete causes damage through invasion, chronic inflammation, and neurodegeneration. The pathophysiology involves chronic inflammatory responses, direct bacterial damage, and proteinopathies.
View Article and Find Full Text PDF[Rapidly progressive dementia by late neurosyphilis (general paresis). Case report].
Rev Med Inst Mex Seguro Soc
September 2024
Instituto Mexicano del Seguro Social, Hospital General de Zona No. 1, Servicio de Medicina Interna. Tepic, Nayarit, México.
Background: The term rapidly progressive dementia (RPD) describes a disorder with rapid progression which leads to a major cognitive decline in less than 1 or 2 years. Neurosyphilis is an infectious cause of RPD and it is classified clinically into early and late forms. The latter affect the brain and spinal cord parenchyma.
View Article and Find Full Text PDFA Study on the Inflammatory Response of the Brain in Neurosyphilis.
Adv Sci (Weinh)
November 2024
Stem cell and Regenerative Medicine Lab, Institute of Clinical Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Neurosyphilis (NS) is a clinical condition caused by infection of the central nervous system (CNS) by Treponema pallidum (Tp) that can lead to asymptomatic meningitis and more serious neurological diseases, such as dementia and blindness. However, current studies on the pathogenesis of NS are limited. Here, through the integration analysis of proteomics and single-cell transcriptomics, Toll-like/NF-κB signaling is identified as the key pathway involved in CNS damage caused by Tp.
View Article and Find Full Text PDFCharacteristic Profiling of Soluble Factors in the Cerebrospinal Fluid of Patients With Neurosyphilis.
J Infect Dis
July 2024
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Background: Soluble inflammatory factors in the cerebrospinal fluid (CSF) of patients with neurosyphilis have been investigated with low-throughput technology. This study aimed to illustrate the characteristics of soluble factor profiles in CSF of patients with neurosyphilis.
Methods: We measured the concentrations of 45 cytokines, chemokines, and growth factors in CSF from 112 untreated syphilis cases, including latent syphilis (LS), asymptomatic neurosyphilis (ANS), meningeal neurosyphilis (MNS), meningovascular neurosyphilis (MVNS), paralytic dementia (PD), and ocular syphilis (OS).
Comprehensive Analysis of Dementia Types and Risk Factors: A Study From a Tertiary Care Center in India.
Cureus
June 2024
Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University) Pune, Pune, IND.
Article Synopsis
- * Conducted between February 2022 and January 2024, the study included 81 patients aged 18 and older and diagnosed based on DSM-V criteria along with cognitive assessments; most participants were over 60 years old, with a predominance of females.
- * Alzheimer's disease emerged as the most common type of dementia (34.5%), followed by vascular and mixed dementia, while several reversible factors such as alcohol and hypothyroid associations were also noted among the cases.
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