The authors analyze two clinical studies in the frame of single-dose treatment of uncomplicated infection of the lower urinary tract. The first study deals with comparison of the effect of netilmicin, ciprofloxacine and aztreonam. The second study deals with pefloxacine and cefuroxim-axetil. As the results implied, both long-term and short-term effectiveness of therapy comparable with other verified regimes was accomplished in female patients who were not pregnant and irrespective of their age. It is necessary to respect the contraindications of therapy. Chemotherapeutics which are appropriate for single-dose therapy of uncomplicated infections of the lower urinary duct include quinolones (pefloxacine, ciprofloxacine), phosphomycin-trometamol, co-trimoxozole a netilmicin. The majority of oral beta-lactam antibiotics cannot be recommended for a single-dose therapy of uroinfections. The authors summarize the advantages of a single-dose therapy of uroinfections and analyze the criteria of significant bacteriuria.
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