The modulatory effects of a glycoprotein-rich endotoxin-free extract of Escherichia coli (OM-89) have been studied using the cotton pellet model of chronic inflammation in the male Wistar rat. OM-89 had a suppressive effect on the size of granuloma surrounding implanted cotton pellets at both 4 and 40 mg/kg given three times weekly. The lower dosage of 4 mg was effective throughout and there was little to be gained by increasing the dose as further reduction of granuloma size was not obtained. Whether given prior to, at the same time as, or after an inflammatory stimulus, OM-89 had suppressive effects. However, if given before, animals at first went through a phase of 'sensitization' before suppressive effects were seen on further exposure to OM-89 antigens, a phenomenon which might have bearing on clinical findings in rheumatoid arthritis. In animals presensitized to a cotton pellet, OM-89 was statistically as effective as indomethacin in suppressing a second granuloma. OM-89 combined with indomethacin showed additive effects and was highly effective. The results indicate that OM-89 could be efficacious in the treatment of chronic inflammatory conditions and there is the possibility that in appropriate circumstances OM-89 might replace some drugs currently used and in others reduce their dosage.

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/34.6.525DOI Listing

Publication Analysis

Top Keywords

om-89
9
chronic inflammation
8
cotton pellet
8
om-89 suppressive
8
suppressive effects
8
om-89 modulation
4
modulation chronic
4
inflammation relevance
4
relevance clinical
4
clinical modulatory
4

Similar Publications

Article Synopsis
  • Bacterial lysates contain immunostimulants that can boost both local and systemic immune responses, aiding in the treatment of infectious diseases and potentially cancer.
  • The review discusses various commercially available bacterial lysates, such as OM-85 and OM-89, showing effectiveness in managing respiratory and urinary tract infections with minimal side effects.
  • Additionally, bacterial lysates may enhance innate immunity for cancer treatment, with research suggesting their potential as adjuvants in therapies for different types of cancer, including bladder cancer and sarcomas.
View Article and Find Full Text PDF

Bacterial Vaccines for the Management of Recurrent Urinary Tract Infections: A Systematic Review and Meta-analysis.

Eur Urol Focus

September 2024

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK; Department of Urology, King's College Hospital NHS Foundation Trust, London, UK.

Background And Objective: Several bacterial immunisations have been developed to reduce the socioeconomic burden of urinary tract infections (UTIs) and the use of prophylactic antibiotics in the management of recurrent UTIs (rUTIs). This systematic review evaluates the effectiveness of vaccinations in preventing rUTIs.

Methods: Medline, Embase, and Web of Science were searched from inception to December 2023.

View Article and Find Full Text PDF

Introduction: Patients with neurogenic lower urinary tract dysfunction (NLUTD) reliant on intermittent self-catheterization for bladder emptying are at an increased risk of recurrent urinary tract infections (rUTI). So far, the most common practice in the prevention of rUTIs is long-term low-dose antibiotic prophylaxis, phytotherapy, and immunomodulation, whereby antibiotic prophylaxis inevitably leads to the emergence of drug-resistant pathogens and difficulty in treating infections. Therefore, non-antibiotic alternatives in the prevention of rUTIs are urgently required.

View Article and Find Full Text PDF

[Non-antibiotic Prophylaxis of Infections].

Praxis (Bern 1994)

June 2022

Klinik für Infektiologie/Spitalhygiene, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Non-antibiotic Prophylaxis of Infections The increasing resistance to antibiotics makes the search for non-antibiotic alternatives for the treatment and prevention of - above all - respiratory and urinary tract infections crucial. Potential non-antibiotic approaches include phytopharmaceuticals (Echinacea purpurea, Pelargonium sidoides, cranberry extract), zinc, immunostimulants (OM-85 BV, OM-89), and behavior modifications. Some of these approaches are promising options; however, a high level of evidence is required before specific recommendations for their use can be made.

View Article and Find Full Text PDF

Objective: To compare recurrent urinary tract infection (rUTI) guidelines from major urological and non-urological organisations internationally and identify areas of consensus and discrepancy.

Methods: PubMed, Google Scholar and the official webpages of major urological, gynaecological, infectious diseases and general practice organisations were searched for rUTI guidelines in March 2022. Nine guidelines were included for review: European Association of Urology, National Institute for Health and Care Excellence (NICE), Society of Obstetricians and Gynaecologists of Canada, American Academy of Family Physicians, Mexican College of Gynaecology and Obstetrics Specialists, Swiss Society of Gynaecology and Obstetrics, Spanish Society of Infectious Diseases and Clinical Microbiology, German Association of Scientific Medical Societies, and the combined American Urological Association/Canadian Urological Association/Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!