AI Article Synopsis
- The study evaluated the induction of cytochrome P4502E1 (CYP2E1) in alcoholics by measuring the ratio of 6-hydroxychlorzoxazone to chlorzoxazone in the blood after CHZ ingestion.
- Alcoholic patients showed a significantly higher ratio (1.05) compared to controls (0.34) within 2 days of alcohol withdrawal, indicating increased CYP2E1 activity, which decreased sharply with a half-life of 2.5 days.
- After 8 and 21 days of abstinence, the metabolic ratio in patients returned to levels similar to controls, and there was no correlation found between alcohol consumption, liver enzyme levels, or smoking status and the hydrox
Article Abstract
To evaluate cytochrome P4502E1 (CYP2E1) induction in alcoholics, the ratio of the concentrations of 6-hydroxychlorzoxazone (6-OH-CHZ) and chlorzoxazone (CHZ) was measured in blood 2 hr after CHZ ingestion using a HPLC method. This ratio was determined in controls and in alcoholic patients after 1, 2, 3, 4, 5, 8, and 21 days withdrawal. It was found to be 0.34 +/- 0.03 in 30 controls and 1.05 +/- 0.14 in 41 alcoholic patients within 2 days following ethanol withdrawal. This ratio decreased rapidly during withdrawal as attested by the short half-life of CYP2E1, which was found to be 2.5 days. Patients tested for CHZ metabolism after 8 or 21 days alcohol abstinence displayed the same ratio as controls [0.35 +/- 0.03 (n = 28) and 0.31 +/- 0.03 (n = 34), respectively]. No correlation was observed between gamma-glutamyltransferase, carbohydrate-deficient transferrin values, the amount of alcohol consumed/day, and the 6-OH-CHZ/CHZ ratio. There was no influence of smoking on the rate of CHZ hydroxylation, because smokers displayed the same ratio as nonsmokers [0.33 +/- 0.025 (n = 62) and 0.33 +/- 0.02 (n = 30), respectively]. The CHZ hydroxylation ratio seems to be a good reflection of the hepatic and extrahepatic CYP2E1 activity in humans.
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| http://dx.doi.org/10.1111/j.1530-0277.1995.tb01516.x | DOI Listing |
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