Further evidence of a dose-response threshold for haloperidol in psychosis.

Am J Psychiatry

Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas, USA.

Published: August 1995

Objective: The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response.

Method: During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol.

Results: No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected.

Conclusions: Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.

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http://dx.doi.org/10.1176/ajp.152.8.1210DOI Listing

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