It has been suggested that G protein-coupled receptors can act as proton transporters, with the activated G protein-coupled receptor transporting H+ across the membrane from the extracellular side to the cytoplasm. In this article, Paul Nederkoorn, Henk Timmerman and Gabriëlle Donné-Op den Kelder summarize the various H+ translocation mechanisms and how these compare with activated G protein-coupled receptors. The G protein, being part of the ternary complex, is proposed to use translocated protons to synthesize GTP from GDP and Pi, thus functioning in a similar manner to ATP synthase. The importance of these events in physiological effects such as signal amplification is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0165-6147(00)89008-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two ligands of Arp2/3 complex, yeast coronin and GMF, interact and synergize in pruning branched actin networks.
J Biol Chem
January 2025
Department of Biology, Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA, USA. Electronic address:
The rapid turnover of branched actin networks underlies key in vivo processes such as lamellipodial extension, endocytosis, phagocytosis, and intracellular transport. However, our understanding of the mechanisms used to dissociate, or 'prune', branched filaments has remained limited. Glia maturation factor (GMF) is a cofilin family protein that binds to Arp2/3 complex and catalyzes branch dissociation.
View Article and Find Full Text PDFNa-concentration dependent conformational switch of oncogene RET G-quadruplex DNA in solution.
Int J Biol Macromol
January 2025
State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:
Proto-oncogene RET is overexpressed in many cancers, and its expression level is positively related to the size and malignancy of the tumors. Effective inhibition of its overexpression can be used to potentially treat cancers. A guanine-rich GC-boxes (I-V) sequence in its promoter region folds into noncanonical G-quadruplex (G4) DNA structures, negatively regulating its expression by interactions with small molecules.
View Article and Find Full Text PDFMacrocyclic peptides as a new class of targeted protein degraders.
RSC Chem Biol
January 2025
School of Chemistry, The University of Sydney Sydney NSW 2006 Australia
Targeted protein degraders, in the form of proteolysis targeting chimaeras (PROTACs) and molecular glues, leverage the ubiquitin-proteasome system to catalytically degrade specific target proteins of interest. Because such molecules can be extremely potent, they have attracted considerable attention as a therapeutic modality in recent years. However, while targeted degraders have great potential, they are likely to face many of the same challenges as more traditional small molecules when it comes to their development as therapeutics.
View Article and Find Full Text PDFEfficiently Re-Utilizing the High-Value Metals in the Spent LiNiMnCoO for the Trifunctional Electrocatalysts by a Novel One-Pot Method.
Small
January 2025
Faculty of Maritime and Transportation, Ningbo University, Ningbo, 315211, P. R. China.
Traditional hydrometallurgy methods for recycling the spent lithium-ion battery materials face some challenges, including the complex processes, and difficulties in separating Ni/Co/Mn. To address these issues, this work proposes a simple one-pot method to achieve a high Li leaching efficiency (99.2%) and simultaneously transform the majority of Ni (99.
View Article and Find Full Text PDFMixed-Dimensional Semiconductors-Based Ternary Circuits with Tunable Negative Transconductance Characteristics.
ACS Appl Mater Interfaces
January 2025
Institute of Advanced Materials and Systems, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Multivalued logic (MVL) systems, in which data are processed with more than two logic values, are considered a viable solution for achieving superior processing efficiency with higher data density and less complicated system complexity without further scaling challenges. Such MVL systems have been conceptually realized by using negative transconductance (NTC) devices whose channels consist of van der Waals (vdW) heterojunctions of low-dimensional semiconductors; however, their circuit operations have not been quite ideal for driving multiple stages in real circuit applications due to reasons such as a reduced output swing and poorly defined logic states. Herein, we demonstrate ternary inverter circuits with near rail-to-rail swing and three distinct logic states by employing vdW p-n heterojunctions of single-walled carbon nanotubes (SWCNT) and MoS where the SWCNT layer completely covers the MoS layer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!