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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights.
Antibiotics (Basel)
January 2025
Department of Internal Medicine, School of Medicine, University of Split, 21000 Split, Croatia.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation, joint pain, and progressive cartilage and bone erosion. Despite advancements in RA management with disease-modifying antirheumatic drugs (DMARDs) and biologics, some patients remain refractory to conventional treatments. Tetracyclines, such as minocycline and doxycycline, exhibit anti-inflammatory and immunomodulatory properties, making them potential supplementary treatments.
View Article and Find Full Text PDFForget me not: The effect of doxycycline on human declarative memory.
Eur Neuropsychopharmacol
December 2024
Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, Joint Center of University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.
Investigations into neuroprotective drugs are in high demand for the treatment of neurodegenerative diseases, such as multiple sclerosis or Alzheimer's disease, but also psychiatric disorders, such as depression, trauma, and substance use. One potential drug class being investigated are tetracyclines impacting on a variety of neuroprotective mechanisms. At the same time, tetracyclines like doxycycline have been suggested to affect human fear and spatial memory as well as reducing declarative memory retention.
View Article and Find Full Text PDFIn situ formed aldehyde-modified hyaluronic acid hydrogel with polyelectrolyte complexes of aldehyde-modified chondroitin sulfate and gelatin: An approach for minocycline delivery.
Carbohydr Polym
November 2024
Contipro a.s. Dolní Dobrouč 401, Dolní Dobrouč, 56102, Czechia.
Polysaccharides like hyaluronan (HA) and chondroitin sulfate (CS) are native of the brain's extracellular matrix crucial for myelination and brain maturation. Despite extensive research on HA and CS as drug delivery systems (DDS), their high water solubility limits their application as drug carriers. This study introduces an injectable DDS using aldehyde-modified hyaluronic acid (HAOX) hydrogel containing polyelectrolyte complexes (PEC) formed with calcium, gelatin, and either CS or aldehyde-modified CS (CSOX) to deliver minocycline for Multiple Sclerosis therapy.
View Article and Find Full Text PDFMinocycline as a prospective therapeutic agent for cancer and non-cancer diseases: a scoping review.
Naunyn Schmiedebergs Arch Pharmacol
May 2024
Department of Animal Biology¸ Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Minocycline is an FDA-approved secondary-generation tetracycline antibiotic. It is a synthetic antibiotic having many biological effects, such as antioxidant, anti-inflammatory, anti-cancer, and neuroprotective functions. This study discusses the pharmacological mechanisms of preventive and therapeutic effects of minocycline.
View Article and Find Full Text PDFThe Role of Epigenetics in Accelerated Aging: A Reconsideration of Later-Life Visual Loss After Early Optic Neuropathy.
J Neuroophthalmol
March 2024
Department of Ophthalmology and the Neuro-Ophthalmology Service (JFR), Massachusetts Eye and Ear and the Harvard Medical School, Boston, Massachusetts; Avedisian and Chobanian School of Medicine (MPS), Boston University, Boston, Massachusetts; Department of Ophthalmology (MPS, DK, BRK), Harvard Medical School, Schepens Eye Research Institute of Mass Eye & Ear, Boston, Massachusetts; Department of Biology (YRL), Whitehead Institute for Biomedical Sciences, MIT, Cambridge, Massachusetts; and Paul F. Glenn Center for Biology of Aging Research (DAS), Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.
Background: In 2005, we reported 3 patients with bilateral optic nerve damage early in life. These patients had stable vision for decades but then experienced significant bilateral vision loss with no obvious cause. Our hypothesis, novel at that time, was that the late decline of vision was due to age-related attrition of retinal ganglion cells superimposed on a reduced neuronal population due to the earlier injury.
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