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Extracorporeal Photopheresis, a Therapeutic Alternative for T cell-mediated Rejection in Renal Transplantation.
Transplant Proc
January 2025
Nefrology Department, Universitary Hospital Virgen de la Arrixaca, Murcia, Spain.
T-cell mediated rejection (TCMR) in renal transplantation, although reduced by better immunosuppressants, still impacts graft survival. TCMR responds to methylprednisolone (MPL) in 60% to 70% of cases, with polyclonal anti-T-lymphocyte antibodies (ATGs) used for severe or corticoresistant cases. When ATG is contraindicated, extracorporeal photopheresis (ECP) may be an alternative.
View Article and Find Full Text PDFHeparin-modified polyether ether ketone hollow fiber membrane with improved hemocompatibility and air permeability used for extracorporeal membrane oxygenation.
Int J Biol Macromol
November 2024
College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China.
To expand the selection of raw material for fabricating extracorporeal membrane oxygenation (ECMO) and promote its application in lung disease therapy, polyether ether ketone hollow fiber membrane (PEEK-HFM) with designable pore characteristics, desired mechanical performances, and excellent biocompatibility was selected as the potential substitute for existing poly (4-methyl-1-pentene) hollow fiber membrane (PMP-HFM). To address the platelet adhesion and plasma leakage issues with PEEK-HFM, a natural anticoagulant heparin was grafted onto the surface using ultraviolet irradiation. Additionally, to explore the substitutability of the heparin layer while considering cost and scalability, a heparin-like layer composed of copolymers of acrylic acid and sodium p-styrenesulfonate was also constructed on the surface of PEEK-HFM Even though the successful grafting of heparin and heparin-like layers on the PEEK-HFM surface reduced the pore parameters, improvements in surface hydrophilicity also prevented the platelet-adhesion phenomenon and improved the anticoagulant behaviour, making it a viable alternative for commercial PMP-HFMs in ECMO production.
View Article and Find Full Text PDFPhotodynamic inactivation of antibiotic-resistant bacteria in whole blood using riboflavin photodynamic method.
Front Microbiol
July 2024
Department of Blood Transfusion Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Treating bacteremia caused by antibiotic-resistant bacteria is a global concern. Antibacterial photodynamic inactivation is a promising strategy to combat it. However, it's challenging to achieve the inactivation of antibiotic-resistant bacteria in whole blood because of its opacity and complexity.
View Article and Find Full Text PDFRole of extracorporeal photopheresis in the management of acute and chronic graft versus disease: current status.
Bone Marrow Transplant
September 2024
Apheresis and Cellular Therapy Unit, Hemotherapy and Hemostasis Department, Institute of Cancer and Hematological Diseases, Hospital Clínic Universitari, Barcelona, Spain.
Article Synopsis
- Extracorporeal photopheresis (ECP) is a therapy that combines cell collection, photosensitizer treatment, and UV light exposure, initially designed for T-cell lymphoma but later adapted for treating graft versus host disease (GvHD) post-transplant.
- ECP has shown high effectiveness for various forms of chronic GvHD and can reduce the need for steroids, improving patient survival rates.
- With new GVHD medications emerging, ECP is now often used alongside these drugs to enhance treatment responses, solidifying its role in managing difficult cases of acute and chronic GvHD.
The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review.
Immunotargets Ther
April 2024
Department of Medical Laboratory Science, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Article Synopsis
- - Hematopoietic stem cell donation treats various cancers but can lead to graft-versus-host disease (GVHD), where donor cells attack the recipient's body, potentially causing severe complications.
- - The text reviews extracorporeal photopheresis, a treatment for GVHD that involves collecting the patient's white blood cells, treating them with a drug, and exposing them to UV light before reinfusing them to reduce the disease's impact.
- - While the treatment shows promise by promoting the death of harmful lymphocytes and increasing regulatory T cells, more research is needed to determine the best practices for selecting patients and administering the therapy.
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