We report a case of collagenous spherulosis of the breast, a very rare underinvestigated lesion which must not be misinterpreted as a malignant epithelial tumour, such as adenoid cystic or signet-ring cell intraductal carcinoma, on histologic slides. The lesion is typically found in association with benign proliferative breast diseases. Prognosis is excellent.
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J Breast Imaging
May 2024
Department of Radiology, University of Missouri - Kansas City School of Medicine, Kansas City, MO, USA.
Acta Cytol
August 2024
IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal.
Background: Fine-needle aspiration cytology (FNAC) is a cornerstone technique for the initial assessment of breast lesions, offering a rapid and minimally invasive option for cytological evaluation. While FNACs can forego the need for core needle biopsies (CNBs), variations in technique, subjective interpretation, and intrinsic limitations present diagnostic challenges. The International Academy of Cytology (IAC) established the Yokohama system and is developing the WHO Reporting System for Breast Cytopathology jointly with IARC, to standardize diagnostic criteria, aiming to enhance diagnostic precision and consistency.
View Article and Find Full Text PDFHum Pathol
June 2024
Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Electronic address:
Collagenous spherulosis (CS) is a rare breast lesion of unknown histogenesis. Adenoid cystic carcinoma (ACC) is a rare basal-like breast carcinoma with low histological grade. CS is a benign lesion but resembles ACC.
View Article and Find Full Text PDFCytopathology
March 2024
Department of General Surgery, All India Institute of Medical Sciences, Raebareli, India.
The co-existence of granulomatous mastitis and collagenous spherulosis in a breast lump is an uncommon finding. The awareness of cytomorphological features can help corroborate a cytological diagnosis. A palpable breast lump in an elderly female warrants urgent attention and fine needle aspiration is a rapid, reliable method of evaluation.
View Article and Find Full Text PDFAm J Surg Pathol
July 2022
Departments of Pathology.
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