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Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances.
Nutr Rev
December 2024
Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
Vitamin A deficiency (VAD) and iron deficiency anemia coexist around the world, particularly in children and women of reproductive age in low- and middle-income countries. Within this scenario, there is a known interaction between vitamin A and iron, and it has been postulated that lack of vitamin A impairs iron metabolism, leading to vitamin A deficiency anemia (VADA). Current animal, epidemiological, and clinical studies support this notion.
View Article and Find Full Text PDFEstablishment of Erythropoietin for physicochemical tests CRS batch 2.
Pharmeur Bio Sci Notes
December 2024
European Directorate for the Quality of Medicines & HealthCare, Department of Biological Standardisation, OMCL Network & HealthCare (DBO), Council of Europe, Strasbourg, France.
Here we report the outcome of a collaborative study aimed at demonstrating the suitability of the candidate Chemical Reference Substance (CRS) as a replacement reference (batch 2) for the physicochemical methods in European Pharmacopoeia monograph . Results from the study demonstrated that for the physicochemical methods described in the monograph - capillary zone electrophoresis, polyacrylamide gel electrophoresis and immunoblotting, peptide mapping and glycan mapping - the candidate CRS is essentially identical to CRS batch 1 and is suitable to be established as Erythropoietin for physicochemical tests CRS batch 2. CRS batch 2 is a freeze-dried preparation presented in vials.
View Article and Find Full Text PDFHypoxia-inducible factor activators: a novel class of oral drugs for the treatment of anemia of chronic kidney disease.
Hematology Am Soc Hematol Educ Program
December 2024
Medical and Research Service, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN.
Anemia is a hallmark of chronic kidney disease (CKD), worsens with disease progression, and profoundly affects a patient's well-being. Major pathogenic factors are inadequate kidney erythropoietin (EPO) production and absolute and functional iron deficiency. The 2 mainstays of current anemia treatment are a) replacement therapy with recombinant EPO or 1 of its glycosylated derivatives, administered subcutaneously or intravenously, and b) intravenous (IV) iron injections.
View Article and Find Full Text PDFErythropoietin levels in geriatric anemia.
J Family Med Prim Care
October 2024
Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
Article Synopsis
- Defects in erythropoietin (EPO) production are linked to anemia, but the effects of aging on EPO levels and different types of geriatric anemia are not well understood.
- The study aimed to compare serum EPO levels in elderly patients with different types of anemia (nutritional anemia, anemia of chronic disease, and unexplained anemia) against non-anemic controls.
- Results showed that geriatric anemia patients had higher serum EPO levels than controls, especially in nutritional anemia cases, while EPO levels correlated inversely with markers of inflammation.
Effects of a single bout of exercise on human hemocytes and serum interleukin 3, erythropoietin, and soluble transferrin receptor in a hot and humid environment.
PeerJ
December 2024
College of Sports Science, Zhuhai College of Science and Technology, Zhuhai, Guangdong, China.
Article Synopsis
- The study examined how exercise at different intensities affects blood cell levels in hot and humid environments (HHEs) and its impact on physical and cognitive performance.* -
- Thirty-two participants were divided into groups based on exercise intensity (55%, 70%, and 85% of VOmax) and compared to a control group, all performed activities in HHE for 30 minutes.* -
- Results showed significant changes in various blood parameters due to exercise intensity, with notable effects on metrics like body mass, hemoglobin, and white blood cell count, particularly in low and moderate intensity groups.*
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