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Case of tizanidine withdrawal showing hallucination, decorticate posture and tremor, with hypersympathetic vital signs.
BMJ Case Rep
March 2024
Department of Neurology, Aizawa Hospital, Matsumoto, Japan
Tizanidine, an α2-adrenergic receptor agonist commonly prescribed as a muscle relaxant, has been associated with limited cases of acute intoxication or withdrawal. Here, we present a case of tizanidine withdrawal in a woman in her 40s who presented with an unusual combination of systemic and neurological symptoms. These included hallucinations, decorticate posture, limb and eyelid tremors, along with hypertension, tachycardia and tachypnoea.
View Article and Find Full Text PDFBuprenorphine induced opioid withdrawal syndrome relieved by adjunctive Magnesium: A clinical trial.
J Subst Use Addict Treat
May 2024
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Introduction: Precipitated opioid withdrawal syndrome (OWS) is a severe and intolerable situation that may occur by a pharmaceutical agent. Reactivation of inhibited N-methyl-d-aspartate (NMDA) receptor in person with prolonged opioid use can led to severe OWS. We conducted a double-blind, randomized clinical trial to assess the effect of magnesium sulfate (MGSO) as an NMDA receptor antagonist on OWS.
View Article and Find Full Text PDFClinical effects of occupational clonidine poisoning and efficacy of extracorporeal blood purification therapies.
Clin Toxicol (Phila)
January 2024
Department of Nephrology, Quzhou TCM Hospital at the Junction of Four Provinces Affiliated to Zhejiang Chinese Medical University, Quzhou, China.
Eliminating the benzos: A benzodiazepine-sparing approach to preventing and treating alcohol withdrawal syndrome.
J Trauma Acute Care Surg
March 2024
From the Department of Surgery (M.A.M., P.R.M., T.M., G.R.S., R.S.M., E.H.S., J.J.H., A.M.N.), and Department of Acute Care Pharmacy (K.A.R.), Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, NC; and Department of Clinical Pharmacy (M.C.), Virginia Commonwealth University Health, Richmond, VA.
Background: Alcohol withdrawal syndrome (AWS) represents significant cost to the hospitalized trauma population from a clinical and financial perspective. Historically, AWS has been managed with benzodiazepines. Despite their efficacy, benzodiazepines carry a heavy adverse effect profile.
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