Mixing of two solutions combined by gravity drainage.

PDA J Pharm Sci Technol

Department of Mechanical Engineering, Northwestern University, Evanston, Illinois, USA.

Published: August 1995

A variety of medical therapies require the mixing of solutions from two separate bags before use. One scenario for the mixing is to drain the solution from one bag into the other by gravity through a short connecting tube. The degree of mixing in the lower bag depends on the relative densities of the two solutions, the geometry of the two bags and the connecting tube, and the placement of the connecting tube. Solutions with densities differing by as much as 12% were mixed by draining the solution from an upper bag into a lower bag for a particular geometric configuration. The two solutions had different electrical conductivities, and the conductivity of the combined solution as it exited from the lower bag was used as a measure of the effectiveness of mixing. When the more dense solution was drained from the upper bag into the less dense solution in a lower bag, mixing was very effective. The incoming jet of high density solution entrained the low density solution. Flow visualization indicated that the incoming jet penetrated to the bottom of the lower bag, and resulting large vortical structures enhanced mixing. When the less dense solution was drained from the upper bag into the more dense solution in the lower bag mixing was less effective. The buoyancy force reduced the momentum of the incoming jet such that it did not penetrate to the bottom of the lower bag, resulting in stratification of the solutions.

Download full-text PDF

Source

Publication Analysis

Top Keywords

lower bag
28
dense solution
16
connecting tube
12
upper bag
12
incoming jet
12
bag
11
solution
9
mixing
8
mixing solutions
8
mixing dense
8

Similar Publications

Factors influencing livestock ownership and herd intensity among smallholder farmers in the Eastern Cape, South Africa.

Heliyon

January 2025

Risk and Vulnerability Science Centre, Faculty of Science and Agriculture, University of Fort Hare, P. Bag X1314, 1 King William's Town Road, Alice, 5700, South Africa.

This study explores the factors influencing smallholder farmers' decisions on livestock ownership and herd size in the context of climate change. A cross-sectional approach was employed, using a multi-stage sampling method to survey 600 smallholder farmers, 495 of whom were engaged in livestock production. Data were collected through a semi-structured questionnaire and analysed using a double hurdle model.

View Article and Find Full Text PDF

Background: Superagers, older adults with exceptional cognitive abilities, show preserved brain structure compared to typical older adults. We investigated whether superagers have biologically younger brains based on their structural integrity.

Methods: A cohort of 153 older adults (aged 61-93) was recruited, with 63 classified as superagers based on superior episodic memory and 90 as typical older adults, of whom 64 were followed up after two years.

View Article and Find Full Text PDF

Neurodegeneration is presumed to be the pathological process measure most proximal to clinical symptom onset in Alzheimer Disease (AD). Structural MRI is routinely collected in research and clinical trial settings. Several quantitative MRI-based measures of atrophy have been proposed, but their low correspondence with each other has been previously documented.

View Article and Find Full Text PDF

Introduction: The Reveos automated blood processing system is the only system developed till date, which can separate whole blood into components on complete automation. Their proprietary LR and NLR blood collection sets have their own advantages and disadvantages. Using LR sets, leukodepleted components can be prepared but individual platelet units cannot be prepared.

View Article and Find Full Text PDF

This study investigates the 3D extrusion printing of a carboxymethyl cellulose (CMC)-gelatin complex coacervate system. Various CMC-gelatin coacervate hydrogels were prepared and analyzed to achieve this goal. The impact of the CMC-gelatin ratio, pH, and total biopolymer concentration on coacervation formation and rheological properties was evaluated to characterize the printability of the samples.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!