Objective: To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.
Subjects And Methods: The urodynamics of 11 healthy males were studied before and during a khat chewing session preceded by indoramin or placebo.
Results: Khat chewing produced a fall in average and maximum urine flow rate. This effect was inhibited by indoramin.
Conclusions: The urinary side-effects of khat chewing are probably mediated through stimulation of alpha 1-adrenergic receptors.
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| http://dx.doi.org/10.1111/j.1464-410x.1995.tb07415.x | DOI Listing |
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