Autologous microvesicles of erythrocyte plasmalemma were obtained by means of ultrasound treatment of erythrocyte suspension. These microvesicles were intravenously (i.v.) injected to pregnant rabbits with artificial bleeding at the 21st day of gestation. Three i.v. injections of microvesicles with 1-3 day interval at the amount equal to 1% of the weight of the circulating erythrocyte plasmalemma increased almost to the control level the number of erythrocytes and hemoglobulin by the 8th day after the bleeding while these indices were much lower in untreated animals.
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J Surg Res
November 2024
Department of Surgery, University of Cincinnati, Cincinnati, Ohio. Electronic address:
Introduction: Large-volume packed red blood cell (pRBC) transfusion is associated with lung injury and worsened outcomes. Amitriptyline reduces lung injury and inflammation in a murine sepsis model. We hypothesized that red cell microparticles (MP) activate endothelial cells, leading to lung injury and that treatment with amitriptyline would blunt the inflammatory response MPs through inhibition of acid sphingomyelinase (ASM).
View Article and Find Full Text PDFJ Surg Res
November 2024
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Introduction: The red blood cell (RBC) storage lesion has been well described in mouse and human blood but not in swine. Understanding the porcine RBC storage lesion is necessary prior to evaluating transfusion of stored packed red blood cells (pRBCs) in polytrauma models. We hypothesized that porcine pRBCs would undergo a similar storage lesion severity after 42 d.
View Article and Find Full Text PDFEnviron Pollut
December 2024
College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, Republic of Korea. Electronic address:
Carbohydr Polym
November 2024
State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; Department of Geriatric Medicine, Wenzhou Ouhai District Chinese and Western Medical Association Hospital, Wenzhou 325000, China. Electronic address:
The development of thrombolytic drug carriers capable of thrombus-targeting, prolonged circulation time, intelligent responsive release, and the ability to inhibit thrombotic recurrences remains a promising but significant challenge. To tackle this, an artificial polysaccharide microvesicle drug delivery system (uPA-CS/HS@RGD-ODE) was constructed. It is composed of cationic chitosan and anionic heparin assembled in a layer by layer structure, followed by surface modification using RGD peptide and 2-(N-oxide-N,N-diethylamino) ethylmethacrylate (ODE) before encapsulation of urokinase-type plasminogen activator (uPA).
View Article and Find Full Text PDFInt J Cardiol
October 2024
3rd Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Background: The study aimed to determine the most crucial parameters associated with CVD and employ a novel data ensemble refinement procedure to uncover the optimal pattern of these parameters that can result in a high prediction accuracy.
Methods And Results: Data were collected from 369 patients in total, 281 patients with CVD or at risk of developing it, compared to 88 otherwise healthy individuals. Within the group of 281 CVD or at-risk patients, 53 were diagnosed with coronary artery disease (CAD), 16 with end-stage renal disease, 47 newly diagnosed with diabetes mellitus 2 and 92 with chronic inflammatory disorders (21 rheumatoid arthritis, 41 psoriasis, 30 angiitis).
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