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Studies pertaining to the monitoring of volatile halogenated anaesthetics in breath by proton transfer reaction mass spectrometry.
J Breath Res
February 2020
Institute for Breath Research, Leopold-Franzens-Universität Innsbruck, Rathausplatz 4, A 6850, Dornbirn, Austria.
Post-operative isoflurane has been observed to be present in the end-tidal breath of patients who have undergone major surgery, for several weeks after the surgical procedures. A major new non-controlled, non-randomized, and open-label approved study will recruit patients undergoing various surgeries under different inhalation anaesthetics, with two key objectives, namely (1) to record the washout characteristics following surgery, and (2) to investigate the influence of a patient's health and the duration and type of surgery on elimination. In preparation for this breath study using proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS), it is important to identify first the analytical product ions that need to be monitored and under what operating conditions.
View Article and Find Full Text PDF[Effects of volatile anesthetics on cortical somatosensory evoked potential and Bispectral index].
Zhonghua Yi Xue Za Zhi
October 2005
Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Objective: To improve the anesthetic environment in monitoring short-latency somatosensory evoked potentials (SSEP) during operation, we compared the effects of different anesthetics on SSEP and Bispectral index (BIS), which aim to select suitable anesthetics and their doses used intraoperatively.
Methods: 60 ASA I-II patients undergoing elective neurosurgery were randomly allocated into three groups: enflurane, isoflurane and desflurane group. The concentration of each volatile anesthetic was increased step by step from 0 to end-tidal 0.
[Effects of intravenous and inhalational anesthetics on short-latency somatosensory evoked potentials].
Zhonghua Yi Xue Za Zhi
March 2004
Deportment of Anesthesia, Huashan Hospital, Fudan University, Shanghai 200040, China.
Objective: To choose suitable general anesthetics dosages when short-latency somatosensory evoked potentials (SLSEP) is monitored during operation.
Methods: 150 ASA I-II neurosurgical patients undergoing elective operations were randomly divided into intravenous anesthesia group of 90 patients and inhalation anesthesia group of 60 patients. The intravenous anesthesia group was further divided into 9 subgroups of 10 patients treated with different anesthetics of different dosages: propofol (1.
PKQuest: volatile solutes - application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics.
BMC Anesthesiol
August 2002
Department of Physiology, 6-125 Jackson Hall, 321 Church St, S, E, Minneapolis, MN 55455.
BACKGROUND: The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for this analysis. PKQuest is a new generic PBPK that is designed to avoid this problem by using a set of "standard human" default parameters that are applicable to most solutes. RESULTS: PKQuest is used to model the human pharmacokinetics of the volatile solutes.
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