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Pseudoprecocious puberty and gynaecomastia as presenting features of Peutz-Jeghers syndrome.
BMJ Case Rep
January 2025
Diabetes and Endocrinology, Children's Health Ireland at Crumlin, Dublin 12, Ireland.
A boy in mid-childhood presented with right-sided gynaecomastia, which was excised. He represented and, on review by endocrinology, Tanner staging showed stage 2 left-sided glandular breast tissue and some features of virilisation. His testicular volumes remained prepubertal (3 mL).
View Article and Find Full Text PDFBiotics as novel therapeutics in targeting signs of skin ageing via the gut-skin axis.
Ageing Res Rev
December 2024
Health and Happiness (H&H) Group, H&H Research, National Food Innovation Hub, Teagasc Moorepark, Fermoy, Co., Cork P61K202, Ireland. Electronic address:
Skin ageing is a phenomenon resulting from the aggregative changes to skin structure and function and is clinically manifested by physical features such as wrinkles, hyperpigmentation, elastosis, telangiectasia, and deterioration of skin barrier integrity. One of the main drivers of skin ageing, UV radiation, negatively influences the homeostasis of cells and tissues comprising the skin by triggering production of immune-mediated reactive oxygen species (ROS) and pro-inflammatory cytokines, as well as a various hormones and neuropeptides. Interestingly, an established link between the gut and the skin coined the 'gut-skin axis' has been demonstrated, with dysbiosis and gut barrier dysfunction frequently observed in certain inflammatory skin conditions and more recently, implicated in skin ageing.
View Article and Find Full Text PDFAn uncommon case of anorectal malignant melanoma (ARMM): Clinical presentation and surgical outcome.
Int J Surg Case Rep
November 2024
Department of Surgery, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Article Synopsis
- Anorectal mucosal melanoma (ARMM) is a rare and aggressive type of melanoma with a poor prognosis, making diagnosis and treatment challenging due to its growth pattern.
- A 61-year-old woman experienced symptoms like anal pain, bleeding, and hyperpigmentation, leading to her undergoing complicated surgery and being diagnosed with malignant melanoma that required further oncology treatment.
- Early diagnosis through awareness of anal hyperpigmentation and surgical excision with proper margins is crucial as it can significantly improve survival rates and reduce local recurrence in ARMM patients.
The scientometric characteristics of lichen planus in stomatology and dermatology journals: A comparative study.
J Dent Sci
October 2024
Department of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- The study compares the publication characteristics of lichen planus (LP) in stomatology vs. dermatology journals, highlighting different research focuses.
- Out of 5633 LP papers, 23.9% were in stomatology and 44.9% in dermatology, with stomatology papers receiving more citations and higher citation density.
- Unique research keywords emerged for each field; stomatology focused on malignant transformation and genetics, while dermatology emphasized drug research and skin observation techniques.
Presumptive Cytomegalovirus Retinitis as a Complication of Dyskeratosis Congenita: A Case Report.
Case Rep Ophthalmol
July 2024
Department of Ophthalmology, Sanmenxia Eye Hospital/Sanmenxia Central Hospital Affiliated to Henan University of Science and Technology, Sanmenxia, China.
Article Synopsis
- Dyskeratosis congenita is a rare genetic disorder affecting skin, nails, and oral mucosa, with uncommon retinal involvement.
- A young male patient with recurrent infections was diagnosed with cytomegalovirus retinitis and subsequently found to have dyskeratosis congenita due to a mutation in the DKC1 gene.
- The case highlights that cytomegalovirus retinitis can indicate serious immunodeficiency in patients with dyskeratosis congenita, necessitating thorough examination.
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