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The Relationship Between PM2.5 and Eight Common Lung Diseases: A Two-Sample Mendelian Randomization Analysis.
Toxics
November 2024
Department of Thoracic, Tianjin Chest Hospital Affiliated to Tianjin University, Tianjin 300051, China.
Air pollutants have both acute and chronic impacts on human health, affecting multiple systems and organs. While PM2.5 exposure is commonly assumed to be strongly associated with all respiratory diseases, this relationship has not been systematically analyzed.
View Article and Find Full Text PDFExpression Levels of MUC5AC and MUC5B in Airway Goblet Cells Are Associated with Traits of COPD and Progression of Chronic Airflow Limitation.
Int J Mol Sci
December 2024
Research Unit of Biomedicine and Internal Medicine, University of Oulu, 902 20 Oulu, Finland.
Mucins 5AC (MUC5AC) and 5B (MUC5B) are the major mucins providing the organizing framework for the airway's mucus gel. We retrieved bronchial mucosal biopsies and bronchial wash (BW) samples through bronchoscopy from patients with chronic obstructive pulmonary disease ( = 38), healthy never-smokers ( = 40), and smokers with normal lung function ( = 40). The expression of MUC5AC and MUC5B was assessed immunohistochemically.
View Article and Find Full Text PDF[Curative Treatment for COPD Based on Differentiation Induction by Synthetic Retinoid Am80 and Development of Inhalation Powder].
Yakugaku Zasshi
January 2025
Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis and emphysema, and current drug treatments is limited to symptomatic therapy. Thus, there is an urgent need for development of new treatments to repair alveolar destruction. To regenerate the destroyed alveoli, we focused on the differentiation of alveolar epithelial progenitor cells into type I or type II alveolar epithelial cells that constitute the alveoli.
View Article and Find Full Text PDFAssociations between short-term exposure to air pollution and acute exacerbation of chronic bronchitis: A time-stratified case-crossover study.
Prev Med
December 2024
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address:
Objective: This study aimed to explore the associations between short-term air pollution exposure and acute exacerbation of chronic bronchitis (AECB).
Methods: AECB data were collected from hospital surveillance systems in Shanghai, China, during 2018-2022. Exposure pollution data were obtained from China high resolution high quality near-surface air pollution datasets and assigned to individuals based on their residential addresses.
Chronic Obstructive Pulmonary Disease: Lifestyle Impact.
Int J Prev Med
November 2024
Department of Nutrition and Dietetics, School of Allied Health Sciences, Faridabad, Haryana, India.
Article Synopsis
- Respiratory infections are a major global health issue, responsible for 7.5 million deaths annually, highlighting their impact on both health and economics.
- Chronic obstructive pulmonary disease (COPD) arises from lifestyle choices and environmental factors, necessitating interventions like smoking cessation, healthy diets, and physical activity to improve lung health.
- European health initiatives focus on early detection and prevention through awareness campaigns, vaccination programs, and nutritional support to reduce the incidence and severity of respiratory diseases.
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