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3D-printed suction clamps for tensile testing of brain tissue.
J Mech Behav Biomed Mater
December 2024
Department of Oral Rehabilitation, University of Otago, 310 Great King Street North, Dunedin, New Zealand.
Article Synopsis
- The study presents a new method for mounting ultra-soft biological tissues using 3D-printed suction clamps, which reduces handling time and skill requirements compared to traditional methods.
- A total of 112 deer brain samples were tested, and 89 tests (85%) were successful, with slippage being the main failure issue, particularly in the medulla oblongata.
- The findings suggest that suction clamps improve efficiency in sample preparation and testing, while the success of testing varies by brain region.
Anemia in Infants and Children: Evaluation and Treatment.
Am Fam Physician
December 2024
Dwight D. Eisenhower Army Medical Center, Fort Eisenhower, Georgia.
Anemia affects more than 269 million children globally, including 1.2 million children in the United States. Although anemia can present with numerous symptoms, children are most often asymptomatic at the time of diagnosis.
View Article and Find Full Text PDF3D-aligned tetrameric ion channels with universal residue labels for comparative structural analysis.
Biophys J
December 2024
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg, Russia; Department of Biochemistry and Biomedical Sciences, Master University, Hamilton, Ontario, Canada. Electronic address:
Despite their large functional diversity and poor sequence similarity, tetrameric and pseudotetrameric potassium, sodium, calcium, and cyclic-nucleotide gated channels, as well as two-pore channels, transient receptor potential channels, and ionotropic glutamate receptor channels, share a common folding pattern of the transmembrane (TM) helices in the pore domain. In each subunit or repeat, two TM helices connected by a membrane-reentering P-loop contribute a quarter to the pore domain. The P-loop includes a membrane-descending helix, P1, which is structurally the most conserved element of these channels, and residues that contribute to the selectivity-filter region at the constriction of the ion-permeating pathway.
View Article and Find Full Text PDFBehavioral decline in Shank3 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes.
Mol Autism
December 2024
Department of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL, 62702, USA.
Article Synopsis
- The SHANK3 gene is linked to autism spectrum disorder (ASD) and is disrupted in Phelan-McDermid syndrome (PMS), which can worsen ASD symptoms; the study explores how Shank3 affects behavioral and cerebellar function in mice.
- Researchers examined various behavioral changes in Shank3 knockout mice at juvenile and adult stages, finding that deletion of Shank3 leads to motor deficits, increased anxiety, and repetitive behaviors, with effects becoming more severe in adults.
- Immunostaining and electrophysiology revealed Shank3 expression in cerebellar granule cells and a connection between behavioral deterioration and changes in synaptic activity, suggesting that age exacerbates behavioral issues due to alterations in cerebellar
Refined Techniques in Tibial Nailing.
J Am Acad Orthop Surg
November 2024
From the Department of Orthopedic Trauma, Harris Methodist Fort Worth Hospital, Fort Worth, TX (Collinge), and the Department of Orthopedic Trauma, Vanderbilt University Medical Center, Nashville, TN (Dr. Rickert, Dr. Mitchell, and Dr. Boyce).
Intramedullary nail fixation of unstable tibial diaphyseal fractures is commonly used with excellent clinical results. Indications for nailing have rapidly expanded over recent years, allowing for more difficult fractures to be addressed with "extreme nailing." Despite its widespread use, evolution of newer nailing systems and varying techniques for insertion bring new difficulties with tibial fracture reduction, and malalignment occurs with relative frequency.
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