A 50-year-old female patient is described with an acquired, persisting and yet incurable erythermalgia featured by symmetric burning pain and red congestion of the extremities secondary to cutaneous vasculitis. A weakly positive antinuclear antibody titer and high titers of antibodies against gastric parietal mucosa cells pointed to an underlying but unclassifiable autoimmune disorder. It is concluded that histopathology of lesional skin contributes to the differential diagnosis of primary and secondary erythermalgia.
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http://dx.doi.org/10.1159/000246692 | DOI Listing |
JAMA
January 2025
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Cureus
September 2024
Internal Medicine Department, Hamad Medical Corporation, Doha, QAT.
Exp Ther Med
July 2024
Dermatology Unit, Department of Medicine, University of Padova, I-35121 Padova, Italy.
The present study reports a case of osimertinib-induced erythromelalgia in a patient with metastatic lung adenocarcinoma. Osimertinib is an antineoplastic drug that irreversibly inhibits the epidermal growth factor receptor (EGFR) pathway by binding to the intracellular receptor tyrosine kinase site, thus preventing EGFR signal transduction. A 77-year-old female with a lung adenocarcinoma recurrence with secondary metastases was prescribed osimertinib therapy.
View Article and Find Full Text PDFCureus
February 2024
Department of Gastroenterology and Hepatology, Ibn Rochd University Hospital Center, Casablanca, MAR.
Erythromelalgia is a rare syndrome with a generally unknown etiology. Whether primary or secondary, this condition is characterized by paroxysmal episodes of erythema, pain, and heat in the extremities. We report two cases of erythromelalgia occurring after the initiation of treatment with infliximab.
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