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The Ku protein family regulates hyperglycemia-induced vascular endothelial cell inflammation by modulating P300 levels.
Exp Cell Res
January 2025
Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Article Synopsis
- Hyperglycemia leads to endothelial inflammation, which significantly contributes to cardiovascular issues in diabetic patients, particularly through mechanisms associated with diabetic kidney injury (DKI).
- P300 and Ese-1 are critical regulators in this process, where P300 enhances Ese-1 expression, promoting inflammation and advancing the progression of DKI by increasing inflammatory markers in both diabetic mice and human kidney cells.
- Silencing P300 mitigates hyperglycemia-induced inflammation, revealing its interaction with the Ku protein family (Ku70/Ku86), which influences inflammation pathways, indicating potential targets for therapeutic interventions in diabetes-related complications.
P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress.
Cell Mol Bioeng
October 2024
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Purpose: P300 is a lysine acetyltransferase that plays a significant role in regulating transcription and the nuclear acetylome. While P300 has been shown to be required for the transcription of certain early flow responsive genes, relatively little is known about its role in the endothelial response to hemodynamic fluid stress. Here we sought to define the role of P300 in mechanotransduction of fluid shear stress in the vascular endothelium.
View Article and Find Full Text PDFCognitive Effects of Transcranial Direct Current Stimulation Plus Robotic Verticalization in Minimally Conscious State.
Biomedicines
October 2024
IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, C.da Casazza, 98124 Messina, Italy.
Article Synopsis
- Transcranial direct current stimulation (tDCS) is a non-invasive method showing promise in treating consciousness disorders when combined with robotic verticalization training (RVT).
- A study involving 24 patients with chronic minimally conscious states assessed the effects of this combination on cognitive and motor recovery.
- Results showed significant improvements in cognitive functioning and reduced P300 latency in patients receiving the combined treatment compared to those who only received RVT, indicating the potential benefits of this integrated therapy.
LncRNA promotes angiogenesis in colorectal cancer by regulating VEGFA expression miR-342-3p and HSP60 binding.
J Biomed Res
October 2024
Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Article Synopsis
- * Long non-coding RNAs (lncRNAs) play a role in CRC by influencing vascular endothelial growth factor (VEGF) expression, which is linked to tumor progression and poor survival outcomes.
- * Research identified a specific lncRNA that, when upregulated in CRC tissues, enhances blood vessel formation and cancer cell migration, suggesting it could be targeted for new CRC therapies and serve as a biomarker for prognosis.
Do changes in cerebral blood flow modulate the amplitudes of P300 during cognitive task?
J Appl Physiol (1985)
November 2024
Department of Engineering, Nara Women's University, Nara, Japan.
A single session of aerobic or resistance training transiently enhances cognitive function, making it a valuable strategy for dementia prevention in the older people. Despite its acknowledged benefits, the precise mechanism behind exercise-induced cognitive improvement remains controversial. In the present study, we investigated the impact of altered cerebral blood flow (CBF) on brain neural activity originating from motor executive and inhibitory processing using electroencephalographic event-related potentials (EEG-ERPs).
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