The parameters of both cellular and humoral non-specific immunity were evaluated in non-small lung cancer patients (n = 26) prior to therapy, in 13 of them after radiotherapy (45 Gy in 22 fractions) and in 13 patients after combined radio-and immunotherapy (Thymex L, 1800 mg in 12 injections á 150 mg i.m., three times a week). Several parameters of general immunocompetence were altered in patients even before any therapy. The radiotherapy caused more severe immunologic disturbances, the cellular immunity being affected more profoundly. Thymex L., when given simultaneously with radiotherapy, prevented this deterioration in a majority of patients.
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