1. The comparative effects of methimazole (MTI), an antithyroid drug, and its S-methyl derivate (MMTI), were studied in vitro on the lymphoproliferative response to lectin in order to point out the free SH group importance. The cell cycle analysis was performed by flow cytometry after cellular DNA staining by propidium iodide. 2. We showed that MTI enhanced the PHA-induced DNA synthesis phase (P < 0.05 from 1 to 100 microns) whereas MMTI had no significant activity. The free SH group seems to be necessary to the MTI immunomodulatory activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0306-3623(95)00011-o | DOI Listing |
Publication Analysis
Top Keywords
free group
12
lymphoproliferative activity
4
activity methimazole
4
methimazole free
4
group dependency
4
dependency comparative
4
comparative effects
4
effects methimazole
4
methimazole mti
4
mti antithyroid
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!