The reaction of acetaldehyde with deoxynucleosides was studied in buffered solutions at room temperature (22-24 degrees C) and neutral pH. Reaction products were obtained with all deoxynucleosides with the exception of thymidine, as shown by reversed-phase HPLC analysis. The order of reactivity was dGuo > dAdo > dCyd, for which three, two and one reaction products, respectively, were obtained. We report here data on the kinetics of the reactions, the stability of the adducts at physiological pH, product yields, UV-spectroscopic data at different pH values, and describe the synthesis, isolation and structural characterization by FAB/MS and NMR of the stable adducts of acetaldehyde with dGuo. Furthermore, the formation of adducts with dGuo by the cooperative reaction of Aa with ethanol was studied.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0009-2797(95)03632-v | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Low-temperature catalytic oxidation of ethanol over doped nickel phosphates.
Environ Sci Pollut Res Int
January 2025
Laboratory of Coordination and Analytical Chemistry (LCCA), Department of Chemistry, Faculty of Sciences, Chouaïb Doukkali University, Ben Maachou Road, B.P: 20, 24000, El Jadida, Morocco.
This work is focused on the synthesis and performance of Ni(PO)-based catalysts doped with Cu, Co, Mn, Ce, Zr, and Mg for the complete oxidation of ethanol, aiming at reducing emissions from ethanol-blended gasoline. Nickel phosphate was prepared via the co-precipitation method, followed by impregnation with the specified dopants. The catalysts were thoroughly characterized by XRD, N-physisorption, XRF, FTIR and Raman spectroscopy, FESEM, NH-TPD, CO-TPD, and H-TPR to explain their performance.
View Article and Find Full Text PDFPollution characteristics and potential sources of Peroxyacetyl Nitrate in a petrochemical industrialized City, Northwest China.
Chemosphere
January 2025
Key Laboratory for Environmental Pollution Prediction and Control, College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China; Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Peroxyacetyl Nitrate (CHC(O)ONO, PAN), a typical secondary product of photochemical reactions, is well known to be a better photochemical indicator due to the only secondary photochemical source in the troposphere. Studies on PAN pollution are sparse in northwest China, resulting in a limited understanding of photochemical pollution in recent years. Herein, the measurement of PAN, O, volatile organic compounds (VOCs), NO, other related species, and meteorological parameters were conducted from May 1 to August 31, 2022, at an urban site in Lanzhou.
View Article and Find Full Text PDFPhotochemical pathways in astronomical ices: A computational study of singlet oxygen reactions with hydrocarbons.
J Chem Phys
January 2025
Fritz Haber Research Center for Molecular Dynamics, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Complex organic molecules are widespread in different areas of the interstellar medium, including cold areas, such as molecular clouds, where chemical reactions occur in ice. Among the observed molecules are oxygen-bearing organic molecules, which are of high interest given their significant role in astrobiology. Despite the observed rich chemistry, the underlying molecular mechanisms responsible for molecular formation in such cold dilute areas are still not fully understood.
View Article and Find Full Text PDFA Prebiotic Route to Lactate from Acetaldehyde, Cyanide and Carbon Dioxide.
Chemistry
December 2024
Department of Chemistry, Nano-Science Center, University of Copenhagen, Universitetsparken 5, Copenhagen Ø, 2100, Denmark.
The atmospheric concentration of carbon dioxide (CO) has fluctuated throughout Earth's history. However, the role of CO in prebiotic chemistry has been predominantly and limitedly postulated as a C1 precursor, which can be reduced to carbon monoxide or methane mimicking the Wood-Ljungdahl pathway. Herein we present neglected roles of CO as an active promoter in accessing biologically important C3-builidng blocks such as lactate, via redox-economic reaction cycles starting from cyanide (C1) and acetaldehyde (C2).
View Article and Find Full Text PDFKinetics and Oligomer Products of the Multiphase Reactions of Hydroxyacetone with Atmospheric Amines, Ammonium Sulfate, and Cloud Processing.
ACS Earth Space Chem
December 2024
Université Paris-Est Créteil and Université Paris Cité, CNRS, LISA, Créteil F-94010, France.
Hydroxyacetone (HA) is an atmospheric oxidation product of isoprene and other organic precursors that can form brown carbon (BrC). Measured bulk aqueous-phase reaction rates of HA with ammonium sulfate, methylamine, and glycine suggest that these reactions cannot compete with aqueous-phase hydroxyl radical oxidation. In cloud chamber photooxidation experiments with either gaseous or particulate HA in the presence of the same N-containing species, BrC formation was minor, with similar mass absorption coefficients at 365 nm (<0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!