All the papers were of a high scientific standard, giving us clearly defined information that will be applicable in the diagnosis and further management of infantile hydrocephalus. Particularly interesting subjects were the comparison of CT and MRI in the evaluation of hydrocephalus and cine MRI, which allows evaluation of the CSF dynamic flows. CBF measurements with xenon CT/CBF imaging or transcranial Doppler examinations of CBF velocity are used much more for evaluation of the shunt indications for shunting and also for definition of the outcome of shunting procedures. Although measurements of physiological CSF parameters are important, studies on the pathophysiology of hydrocephalus should be focused on the changes in CBF in hydrocephalus patients. The key points and conclusions presented by each author are discussed and the prospects mentioned for the future in neuroimaging and functional examination in hydrocephalus.
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http://dx.doi.org/10.1007/BF00334969 | DOI Listing |
Mol Neurobiol
January 2025
Research and Innovation Center, Shanghai Pudong Hospital, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 200433, China.
Investigating plasma proteomic signatures of dementia offers insights into its pathology, aids biomarker discovery, supports disease monitoring, and informs drug development. Here, we analyzed data from 48,367 UK Biobank participants with proteomic profiling. Using Cox and generalized linear models, we examined the longitudinal associations between proteomic signatures and dementia-related phenotypes.
View Article and Find Full Text PDFCurr Pain Headache Rep
January 2025
Faculty of Health Sciences, Universidade da Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal.
Introduction: Central Post-Stroke Pain (CPSP) is a debilitating condition with a significant prevalence in stroke survivors. Set apart by its refractory to treatment neuropathic pain, it appears to arise from lesions in the spino-thalamo-cortical pathways, particularly in the thalamus. Despite advances in neuroimaging techniques, the pathophysiology of CPSP remains poorly understood, with limited diagnostic criteria and therapeutic approaches.
View Article and Find Full Text PDFNeuroscience
January 2025
Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:
Abnormal functional and structural connectivity of brain networks is commonly observed in patients with type 2 diabetes mellitus (T2DM) and accompanied bycognitive impairment. In this study, we revealed differences in brain structure in T2DM using a Morphometric Similarity Network (MSN) method, which quantifies structural similarities between brain regions. The associations between T2DM-associated changes in morphometric similarity (MS) and gene expression were analyzed to explore the molecular and cellular mechanism underlying MS changes in T2DM.
View Article and Find Full Text PDFNeuroimage
January 2025
Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Brain and Education Innovation, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai, China. Electronic address:
Environmental and social changes during early school age have a profound impact on brain development. However, it remains unclear how the brains of typically-developing children adjust white matter to optimize network topology during this period. This study aims to propose the fiber length distribution as a novel nodal metric to capture the continuous maturation of brain network.
View Article and Find Full Text PDFNeuroimage
January 2025
IRCCS Istituto delle Scienze Neurologiche di Bologna.
Objective: The aim of the present study is to examine the relationship between EEG measures and functional recovery in right-hemisphere stroke patients.
Methods: Participants with stroke (PS) and neurologically unimpaired controls (UC) were enrolled. At enrolment, all participants were assessed for motor and cognitive functioning with specific scales (motricity index, trunk control test, Level of Cognitive Functioning, and Functional Independence Measure (FIM).
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