The origin of autoreactive CD4-CD8- T cells is largely unknown. In TCR transgenic (Tg) mice expressing the cognate class I MHC antigen, CD4-CD8- T cells differed depending on characteristics of Tg-TCR/antigen interaction. Tg-TCR/CD3lo CD4-CD8- T cells expressing the NK1.1 marker were observed only for a Tg-TCR whose stimulation by antigen was independent of CD8. Unlike normal T cells, which have essentially TCR-associated zeta homodimers, these cells had a high proportion of TCR-associated zeta-Fc epsilon RI gamma heterodimers. They were also characterized by an unusually high content of Fc epsilon RI gamma mRNA and low content of mRNA encoding CD3 epsilon, CD3 gamma, CD3 delta, and zeta. Based on their phenotype and selection requirements, it is proposed that CD4-CD8- thymic precursor cells can be driven along the CD4-CD8-NK1.1+ pathway following coreceptor-independent TCR signaling at an intrathymic stage when Fc epsilon RI gamma and CD3 components are coexpressed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/1074-7613(95)90172-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metabolic profiles of meconium in preeclamptic and normotensive pregnancies.
Metabolomics
January 2025
Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Introduction: Preeclampsia (PE) is a common vascular pregnancy disorder affecting maternal and fetal metabolism with severe immediate and long-term consequences in mothers and infants. During pregnancy, metabolites in the maternal circulation pass through the placenta to the fetus. Meconium, a first stool of the neonate, offers a view to maternal and fetoplacental unit metabolism and could add to knowledge on the effects of PE on the fetus and newborn.
View Article and Find Full Text PDFSquamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus.
Front Immunol
January 2025
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Squamate reptiles are amongst the most successful terrestrial vertebrate lineages, with over 10,000 species across a broad range of ecosystems. Despite their success, squamates are also amongst the least studied lineages immunologically. Recently, a universal lack of γδ T cells in squamates due to deletions of the genes encoding the T cell receptor (TCR) γ and δ chains was discovered.
View Article and Find Full Text PDFX-Linked Autism Type 9 Caused by a Hemizygote Pathogenic Variant in the Gene: Etiological Diagnosis in an Adult Male with Moderate Intellectual Disability.
Int Med Case Rep J
January 2025
Vincent van Gogh Centre of Excellence for Neuropsychiatry, Venray, The Netherlands.
Introduction: Levocarnitine is essential for brain functioning and fatty acid metabolism and stems largely from dietary sources. The Epsilon-Trimethyllysine Hydroxylase () gene encodes the enzyme N-Trimethyllysine hydroxylase (TMLH) which catalyses the first step in the biosynthesis of carnitine. Lack of TMLH enzyme activity is associated with developmental delay and autistic behaviours described as X-linked recessive autism, type 6 (OMIM#300872).
View Article and Find Full Text PDFEffects of hydrogen on microstructure evolution and mechanical properties of TB8 titanium alloy.
PLoS One
January 2025
School of Petrochemical Engineering, Changzhou University, Changzhou, China.
The influence of varying hydrogen content on the microstructure, mechanical properties, and fracture behavior of the metastable β titanium alloy TB8 after hydrogen charging has been investigated in this study. Several characterization methods, including optical microscopy (OM), x-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM), were employed to comprehensively analyze the alloy. The results show that with the addition of hydrogen, hydrogen mainly accumulated at grain boundaries in the form of hydrides.
View Article and Find Full Text PDFκ/β-GaO Type-II Phase Heterojunction.
Adv Mater
January 2025
Advanced Semiconductor Laboratory, Electrical and Computer Engineering Program, Division of Computer, Electrical, and Mathematical Sciences and Engineering (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Ultrawide-bandgap gallium oxide (GaO) holds immense potential for crucial applications such as solar-blind photonics and high-power electronics. Although several GaO polymorphs, i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!