[Functional state of the liver in workers exposed to multi-component chemical mixture in the production of plastic construction materials].

The examination covered 52 workers engaged into production of linoleum and polyvinylchloride self-sticking coating. The workers were exposed to mixture of chemicals, especially to low concentrations of diethylhexyl phthalate (dioctyl phthalate). Detoxication in the liver was assessed through developed antipyrine test with detection of total and free derivatives of antipyrine in the urine. If compared to other functional tests, the changes in activity of enzymes dependent on cytochrome P-450 were considerably prevalent and marked. Divergent changes were seen--activated enzymes of antipyrine oxidation (I phase of the metabolism) and depression of those participating in the metabolites conjugation. The findings were considered as molecular results of toxic influence on the liver.